1.14.19.9: tryptophan 7-halogenase
This is an abbreviated version!
For detailed information about tryptophan 7-halogenase, go to the full flat file.
Word Map on EC 1.14.19.9
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1.14.19.9
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fadh2-dependent
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dichlorination
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halometabolites
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rebeccamycin
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alpha-ketoglutarate-dependent
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haloperoxidases
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syringomycin
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alphakg-dependent
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pyrrolnitrin
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alphakg
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l-thr
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organohalogens
- 1.14.19.9
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fadh2-dependent
-
dichlorination
-
halometabolites
- rebeccamycin
-
alpha-ketoglutarate-dependent
- haloperoxidases
-
syringomycin
-
alphakg-dependent
- pyrrolnitrin
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alphakg
- l-thr
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organohalogens
Reaction
Synonyms
EC 1.14.14.7, FAD-dependent halogenase, flavin-dependent halogenase, flavin-dependent tryptophan halogenase, halogenase, KtzQ, L-tryptophan-7-halogenase, PrnA, RebH, Trp 7-hal, Trp halogenase, Trp-7-Hal, Trp-7-halogenase
ECTree
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Engineering
Engineering on EC 1.14.19.9 - tryptophan 7-halogenase
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F103A
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the mutant shows increased Km and reduced kcat values compared to the wild type enzyme
H101A
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the mutant shows increased Km and reduced kcat values compared to the wild type enzyme
W455A
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the mutant shows increased Km and reduced kcat values compared to the wild type enzyme
additional information
gene disruption mutant, no production of pyrroindomycin B, but still production of pyrroindomycin A
additional information
for optimization of the enzymatic regioselective halogenation process, a method that is easily scalable up to gram scale is established. An active FAD-dependent halogenase is co-immobilized with all auxiliary enzymes necessary for halogenation, formation of cross-linked enzyme aggregates (CLEAs) might stabilize its quaternary structure
additional information
Lentzea aerocolonigenes 39243
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gene disruption mutant, no production of pyrroindomycin B, but still production of pyrroindomycin A
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