Information on EC 7.4.2.3 - mitochondrial protein-transporting ATPase

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IUBMB Comments
A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
+
mitochondrial-protein[side 1]
=
+
+
mitochondrial-protein[side 2]
Synonyms
hsp70, hsp70 chaperone, tom complex, mthsp70, mitochondrial hsp70, dnak chaperone, protein translocase, mhsp70, hsp70 atpase, pam18, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + mitochondrial-protein[side 1] = ADP + phosphate + mitochondrial-protein[side 2]
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