Literature summary for 7.4.2.3 extracted from

Yamamoto, H.; Momose, T.; Yatsukawa, Y.; Ohshima, C.; Ishikawa, D.; Sato, T.; Tamura, Y.; Ohwa, Y.; Endo, T.
Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane (2005), FEBS Lett., 579, 507-511.

Search for more literature for 7.4.2.3

Application

Application	Comment	Organism
additional information	Tim15/Zim17 cooperates with mtHsp70 to faciliate import of presequence-containing proteins into the matrix	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Saccharomyces cerevisiae	5739	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	and strains PK82 and PK83	-
Saccharomyces cerevisiae PK81	-	and strains PK82 and PK83	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O	ATP appears more favourable for mtHsp70 binding to GST-Tim15 than ADP, ruling out that GST-Tim15 is non-specifically trapped by mtHsp70 as an unfolded chaperone substrate	Saccharomyces cerevisiae	ADP + phosphate	-	?
ATP + H2O	ATP appears more favourable for mtHsp70 binding to GST-Tim15 than ADP, ruling out that GST-Tim15 is non-specifically trapped by mtHsp70 as an unfolded chaperone substrate	Saccharomyces cerevisiae PK81	ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
mitochondrial hsp70	-	Saccharomyces cerevisiae
mtHSP70	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)