Information on EC - phosphoribosylaminoimidazole carboxylase

for references in articles please use BRENDA:EC4.1.1.21
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
       phosphoribosylaminoimidazole carboxylase
IUBMB Comments
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC, 5-(carboxyamino)imidazole ribonucleotide synthase and EC, 5-(carboxyamino)imidazole ribonucleotide mutase . 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
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Word Map
  • saicars
  • n5-cair
  • phosphoribosylaminoimidazolesuccinocarboxamide
  • 4-carboxy-5-aminoimidazole
  • aircs
  • n5-carboxyaminoimidazole
  • samdc
  • analysis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
5-Amino-1-ribosylimidazole 5-phosphate carboxylase, 5-Phosphoribosyl-5-aminoimidazole carboxylase, AdeD, AIR carboxylase, AIRC, aminoimidazole ribonucleotide carboxylase, Carboxylyase, phosphoribosylaminoimidazole, class II PurE, PAICS, phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, more
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2
show the reaction diagram
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