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Disease on EC 4.1.1.21 - phosphoribosylaminoimidazole carboxylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome.
Adenocarcinoma of Lung
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Roles of highly expressed PAICS in lung adenocarcinoma.
Breast Neoplasms
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Roles of highly expressed PAICS in lung adenocarcinoma.
Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer.
Carcinogenesis
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2.
Carcinoma, Non-Small-Cell Lung
Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer.
Colorectal Neoplasms
Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer.
PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer.
Glioma
PAICS is related to glioma grade and can promote glioma growth and migration.
Lung Neoplasms
Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer.
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.
Roles of highly expressed PAICS in lung adenocarcinoma.
Melanoma
Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling.
Microphthalmos
Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.
Neoplasm Metastasis
Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer.
PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer.
Neoplasms
A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.
A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression.
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer.
Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders.
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2.
PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression.
PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer.
Roles of highly expressed PAICS in lung adenocarcinoma.
Neuroblastoma
Combinatorial targeting of MTHFD2 and PAICS in purine synthesis as a novel therapeutic strategy.
Pancreatic Neoplasms
PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression.
Perinatal Death
PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome.
phosphoribosylaminoimidazole carboxylase deficiency
PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2.
PAICS deficiency, a new defect of de novo purine synthesis resulting in multiple congenital anomalies and fatal outcome.
Prostatic Neoplasms
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer.
Expression and role of PAICS, a de novo purine biosynthetic gene in prostate cancer.
Roles of highly expressed PAICS in lung adenocarcinoma.
Stomach Neoplasms
PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2.
Urinary Bladder Neoplasms
A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression.
Uterine Cervical Neoplasms
Potential suppressive functions of microRNA-504 in cervical cancer cells malignant process were achieved by targeting PAICS and regulating EMT.