Literature summary for 4.1.1.21 extracted from

Firestine, S.M.; Poon, S.W.; Mueller, E.J.; Stubbe, J.; Davisson, V.J.
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms ? (1994), Biochemistry, 33, 11927-11934.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Gallus gallus
-	Escherichia coli

Inhibitors

Inhibitors	Comment	Organism	Structure
4-Nitro-5-aminoimidazole ribonucleotide	steady-state inhibitor	Escherichia coli
4-Nitro-5-aminoimidazole ribonucleotide	tight-binding inhibitor	Gallus gallus

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	two enzymes PurK and PurE are required for the reaction	-
Gallus gallus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2	PurK accelerates the growth of the organism by coupling ATP hydrolysis to HCO3-activation and subsequent N-carboxylation of 1-(5-phosphoribosyl)-5-aminoimidazole	Escherichia coli	1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate	-	?
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2	1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate is formed directly from 1-(5-phosphoribosyl)-5-aminoimidazole + CO2	Gallus gallus	1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate	-	?

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Release 2023.1 (January 2023)