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Information on EC 2.4.1.198 - phosphatidylinositol N-acetylglucosaminyltransferase

for references in articles please use BRENDA:EC2.4.1.198
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IUBMB Comments
Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
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Word Map
  • 2.4.1.198
  • paroxysmal
  • nocturnal
  • hemoglobinuria
  • marrow
  • gpi-anchored
  • genotoxicity
  • x-linked
  • anemia
  • aplastic
  • hemolysis
  • cytometric
  • micronucleus
  • granulocytes
  • analysis
  • micronucleated
  • intravascular
  • n-ethyl-n-nitrosourea
  • glycosylphosphatidylinositol-anchored
  • gpi-linked
  • gpi-deficient
  • comet
  • complement-mediated
  • pigret
  • clastogenic
  • cd59-negative
  • gpi-aps
  • mn-rets
  • myelodysplastic
  • repeat-dose
  • eculizumab
  • enu-induced
  • haemopoietic
  • 4-nitroquinoline-1-oxide
  • enu-treated
  • cd59-deficient
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
pig-a, dscr5, gpi-gnt, gpi19, gpi-n-acetylglucosaminyltransferase, gpi-glcnac transferase, afpig-a, gpi-n-acetylglucosaminyltransferase complex, down syndrome critical region protein 5, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol
show the reaction diagram
In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
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