Cloned (Comment) | Organism |
---|---|
hGPI1, DNA sequence determination, coexpression as GST-tagged protein in human B lymphoblastoid JY25 or JY5 cells with the other three GST- or FLAG-tagged protein of the active protein complex | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Saccharomyces cerevisiae | 5783 | - |
membrane | - |
Homo sapiens | 16020 | - |
membrane | - |
Saccharomyces cerevisiae | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Saccharomyces cerevisiae |
additional information | - |
enzyme is active in a complex of at least 4 proteins, termed GPI1, PIG-A, PIG-C and PIG-H, in which GPI1 is absolutely essential for stabilization | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme is active in a complex of at least 4 proteins, termed GPI1, PIG-A, PIG-C and PIG-H, in which GPI1 is absolutely essential for stabilization | ? | - |
? | |
additional information | Saccharomyces cerevisiae | glycosylphosphatidylinositol anchoring is essential for transport of cell surface proteins and enzyme deficieny leads to defective cell wall synthesis and cell death | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + phosphatidylinositol | Homo sapiens | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
UDP-N-acetyl-D-glucosamine + phosphatidylinositol | Saccharomyces cerevisiae | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q9BRB3 | gene hGPI1 | - |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is active in a complex of at least 4 proteins, termed GPI1, PIG-A, PIG-C and PIG-H, in which GPI1 is absolutely essential for stabilization | Homo sapiens | ? | - |
? | |
additional information | glycosylphosphatidylinositol anchoring is essential for transport of cell surface proteins and enzyme deficieny leads to defective cell wall synthesis and cell death | Saccharomyces cerevisiae | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + phosphatidylinositol | substrate specificity | Homo sapiens | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
UDP-N-acetyl-D-glucosamine + phosphatidylinositol | enzyme complex | Homo sapiens | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
UDP-N-acetyl-D-glucosamine + phosphatidylinositol | enzyme complex | Saccharomyces cerevisiae | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
UDP-N-acetyl-D-glucosamine + phosphatidylinositol | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | Homo sapiens | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? | |
UDP-N-acetyl-D-glucosamine + phosphatidylinositol | involved in the first step of glycosylphosphatidylinositol, i.e. GPI, membrane anchor formation of surface glycoproteins | Saccharomyces cerevisiae | UDP + N-acetyl-D-glucosaminyl-phosphatidylinositol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GPI-GlcNAc transferase | - |
Saccharomyces cerevisiae |
GPI-GlcNAc transferase | - |
Homo sapiens |
GPI-GnT | - |
Saccharomyces cerevisiae |
GPI-GnT | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |