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Information on EC 2.1.1.184 - 23S rRNA (adenine2085-N6)-dimethyltransferase

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IUBMB Comments
ErmC is a methyltransferase that confers resistance to the macrolide-lincosamide-streptogramin B group of antibiotics by catalysing the methylation of 23S rRNA at adenine2085.
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Word Map
  • 2.1.1.184
  • macrolide
  • methyltransferases
  • macrolide-lincosamide-streptogramin
  • lincosamide
  • unmethylated
  • streptogramine
  • s-adenosyl-l-methionine-dependent
  • stall
  • mtases
  • medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
2
+
adenine2085 in 23S rRNA
=
2
+
N6-dimethyladenine2085 in 23S rRNA
Synonyms
ermc', ermc methylase, ermc' methyltransferase, ermc methyltransferase, erythromycin resistance protein, rrna methyltransferase ermc', ermc 23s rrna methyltransferase, ermc 23 s rrna methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + adenine2085 in 23S rRNA = 2 S-adenosyl-L-homocysteine + N6-dimethyladenine2085 in 23S rRNA
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