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Literature summary for 2.1.1.184 extracted from
- Induction of ermC methylase in the absence of macrolide antibiotics and by pseudomonic acid A (1989), J. Bacteriol., 171, 4518-4520.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | P13956 | - |
- |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Bacillus subtilis | induction is due to a posttranscriptional mechanism in which the inducer activates translation of methylase mRNA by binding to unmethylated (erythromycin-sensitive) ribosomes and stalling them in the leader region. Pseudomonic acid A can also induce methylase synthesis. Isoleucine starvation has a similar effect on ribosomes translating the ermC leader region to cause induction of methylase synthesis. Requirement for ribosome stalling and destabilization of a stem-loop structure and demonstration that stalling can occur without macrolide-bound ribosomes | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme confers resistance to macrolide-lincosamide-streptogramin B antibiotics | Bacillus subtilis |
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