Bacillus subtilis |
induction is due to a posttranscriptional mechanism in which the inducer activates translation of methylase mRNA by binding to unmethylated (erythromycin-sensitive) ribosomes and stalling them in the leader region. Pseudomonic acid A can also induce methylase synthesis. Isoleucine starvation has a similar effect on ribosomes translating the ermC leader region to cause induction of methylase synthesis. Requirement for ribosome stalling and destabilization of a stem-loop structure and demonstration that stalling can occur without macrolide-bound ribosomes |
additional information |