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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184E128A kcat/KM for S-adenosyl-L-methionine is 46% of wild type value. kcat/KM for RNA is 59% of wild type value. No difference in generating erythromycin resistance when compared to the wild-type enzyme -, 662611
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184E202A mutant of a residues positioned on the surface of the small domain, does not display substantial defects in activity compared with the wild-type enzyme. kcat/Km for S-adenosyl-L-methionine is 32% of the wild-type value. kcat/Km for RNA is 40% of wild-type value -, 705957
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184F163A kcat/KM for S-adenosyl-L-methionine is 67% of wild type value. kcat/KM for RNA is 28% of wild type value. Mutant enzyme still mediates erythromycin resistance, although at reduced level 662611
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184K133A decreased ability in rendering DH5alpha cells resistant to erythromycin, suggesting that this amino acid is not absolutely indispensable for the ErmC' activity, but might be involved in important RNA-protein interactions. No change in affinity towards the RNA substrate. kcat/Km for S-adenosyl-L-methionine is% of the wild-type value. kcat/Km for RNA is 27% of wild-type value. kcat/Km for S-adenosyl-L-methionine is 13% of the wild-type value. kcat/Km for RNA is% of wild-type value -, 705957
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184K166A kcat/KM for S-adenosyl-L-methionine is 74% of wild type value. kcat/KM for RNA is 58% of wild type value. Little difference in generating erythromycin resistance when compared to the wild-type enzyme 662611
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184K168A kcat/KM for S-adenosyl-L-methionine is 59% of wild type value. kcat/KM for RNA is 70% of wild type value. No difference in generating erythromycin resistance when compared to the wild-type enzyme -, 662611
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184K197A mutant of a residues positioned on the surface of the small domain, does not display substantial defects in activity compared with the wild-type enzyme. kcat/Km for S-adenosyl-L-methionine is 67% of the wild-type value. kcat/Km for RNA is 50% of wild-type value -, 705957
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184K197A/N200A/E202A/K204A/K205A the five mutations together do not show a visible cumulative effect on the ErmC' activity in vivo 705957
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184K204A mutant of a residues positioned on the surface of the small domain, does not display substantial defects in activity compared with the wild-type enzyme. kcat/Km for S-adenosyl-L-methionine is 73% of the wild-type value. kcat/Km for RNA is 89% of wild-type value 705957
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184K205A mutant of a residues positioned on the surface of the small domain, does not display substantial defects in activity compared with the wild-type enzyme. kcat/Km for S-adenosyl-L-methionine is 63% of the wild-type value. kcat/Km for RNA is 92% of wild-type value 705957
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