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Results 1 - 8 of 8
EC Number Inhibitors Commentary Structure
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1842-([[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl][3-(1H-imidazol-1-yl)propyl]amino]methyl)-1H-isoindole-1,3(2H)-dione i.e. PD00556 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1844-methyl-2,6-di[(4-methylphenyl)thio]nicotinonitrile i.e. RF00667 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184more the crystal structure of ErmCΒ’ methyltransferase is used as a target for structure-based virtual screening of a database composed of 58679 lead-like compounds. Among 77 compounds selected for experimental validation (63 predicted to bind to the catalytic pocket and 14 compounds predicted to bind to the putative RNA binding site), several novel inhibitors are found that decrease the minimal inhibitory concentration of a macrolide antibiotic erythromycin toward an Escherichia coli strain that constitutively expresses ErmC'. Analysis of docking models of the identified inhibitors suggests a novel strategy to develop potent and clinically useful inhibitors Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184N6-dimethyladenine2085 containing 23S rRNA linear competitive inhibition kinetics with RNA as the variable substrate, mixed inhibition with S-adenosyl-L-methionine as the variable substrate Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184nicotinaldehyde-N-[3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]hydrazone i.e. HTS12610 Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184S-adenosyl-L-homocysteine linear competitive pattern with S-adenosyl-L-methionine as the variable substrate, and a mixed inhibition kinetics with RNA Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184S-adenosyl-L-homocysteine - Go to the Ligand Summary Page
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.184sinefungin competitive Go to the Ligand Summary Page
Results 1 - 8 of 8