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Information on EC 1.5.1.43 - carboxynorspermidine synthase

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IUBMB Comments
The reaction takes place in the opposite direction. Part of a bacterial polyamine biosynthesis pathway. L-aspartate 4-semialdehyde and propane-1,3-diamine/putrescine form a Schiff base that is reduced to form carboxynorspermidine/carboxyspermidine, respectively . The enzyme from the bacterium Vibrio cholerae is essential for biofilm formation . The enzyme from Campylobacter jejuni only produces carboxyspermidine in vivo even though it also can produce carboxynorspermidine in vitro .
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The enzyme appears in viruses and cellular organisms
Synonyms
ASA-DAP Schiff base reductase, Atu4170, C-NSPD synthase, CANSDH, carboxy(nor)spermidine dehydrogenase, carboxynorspermidine dehydrogenase, carboxynorspermidine synthase, carboxyspermidine dehydrogenase, CASDH, VC1624, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
carboxynorspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
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(1)
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carboxyspermidine + H2O + NADP+ = L-aspartate 4-semialdehyde + putrescine + NADPH + H+
show the reaction diagram
(2)
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