Ligand L-aspartic 4-semialdehyde

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Basic Ligand Information

Molecular Structure
Picture of L-aspartic 4-semialdehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H7NO3
L-aspartic 4-semialdehyde
HOSWPDPVFBCLSY-VKHMYHEASA-N
Synonyms:
(S)-aspartate-4-semialdehyde, (S)-aspartate 4-semialdehyde, aspartate-4-semialdehyde, aspartate-beta-semialdehyde, aspartate 4-semialdehyde, aspartate beta-semialdehyde, aspartic beta-semialdehyde, L-2-amino-4-oxobutanoate, L-aspartate-4-semialdehyde, L-aspartate-semialdehyde, L-aspartate 4-semialdehyde, L-aspartate beta-semialdehyde, L-aspartate semialdehyde


Show all pahtways known for Show all BRENDA pathways known for L-aspartic 4-semialdehyde

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+ = carboxynorspermidine + NADP+ + H2O
show the reaction diagram
-
L-2-amino-4-oxobutanoate + L-glutamate = L-2,4-diaminobutanoate + 2-oxoglutarate
show the reaction diagram
-
glycerone phosphate + L-aspartate 4-semialdehyde = 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-2,4-diaminobutanoate + pyruvate = L-2-amino-4-oxobutanoate + L-alanine
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+ = carboxynorspermidine + NADP+ + H2O
show the reaction diagram
-
L-2-amino-4-oxobutanoate + L-glutamate = L-2,4-diaminobutanoate + 2-oxoglutarate
show the reaction diagram
-
ATP + L-aspartate 4-semialdehyde = ?
show the reaction diagram
-
glycerone phosphate + L-aspartate 4-semialdehyde = 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-2,4-diaminobutanoate + 2-oxoglutarate = L-aspartate 4-semialdehyde + L-glutamate
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
crude extract
-

Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
mixed inhibition versus L-homoserine and ATP
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (56 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
2.1
-
wild-type enzyme
0.2
-
pH 7.2, 30°C

KM Value (102 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4.68
-
pH 7.5, 37°C, Vmax: 35 micromol/min/mg carboxynorspermidine
4.5
-
pH 8.5, 25ºC
4.5
-
pH 8.5, 25°C
0.0056
-
pH 7.2, 30°C

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for L-aspartic 4-semialdehyde

ChEBI
PubChem
ChEBI
PubChem