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EC 3.3.2.11 Details
show Brenda entryEC number
3.3.2.11
Accepted name
cholesterol-5,6-oxide hydrolase
Reaction
(1) 5,6α-epoxy-5α-cholestan-3β-ol + H2O = 5α-cholestane-3β,5α,6β-triol;;(2) 5,6β-epoxy-5β-cholestan-3β-ol + H2O = 5α-cholestane-3β,5α,6β-triol
Other name(s)
cholesterol-epoxide hydrolase,
ChEH
Systematic name
5,6α-epoxy-5α-cholestan-3β-ol hydrolase
Comment
The enzyme appears to work equally well with either epoxide as substrate [3]. The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].
History
created 2006
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1 Oxidoreductases
3 Hydrolases
3.3.2.1 isochorismatase
