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EC 3.3.2.6 Details
show Brenda entryEC number
3.3.2.6
Accepted name
leukotriene-A4 hydrolase
Reaction
leukotriene A4 + H2O = leukotriene B4
Other name(s)
LTA4 hydrolase,
LTA4H,
leukotriene A4 hydrolase
Systematic name
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase
CAS registry number
90119-07-6
Comment
This is a bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities [4,6]. It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates [6] (see EC 3.4.11.6, aminopeptidase B). It also converts leukotriene A4 into leukotriene B4, unlike EC 3.3.2.10, soluble epoxide hydrolase, which converts leukotriene A4 into 5,6-dihydroxy-7,9,11,14-icosatetraenoic acid [3,4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol-5,6-oxide hydrolase) [5].
History
created 1989, modified 2006
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1 Oxidoreductases
3 Hydrolases
3.3.2.1 isochorismatase
