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EC 3.3.2.12 Details
show Brenda entryEC number
3.3.2.12
Accepted name
oxepin-CoA hydrolase
Reaction
2-oxepin-2(3H)-ylideneacetyl-CoA + H2O = 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde
Other name(s)
paaZ (gene name)
Systematic name
2-oxepin-2(3H)-ylideneacetyl-CoA hydrolase
Comment
The enzyme from Escherichia coli is a bifunctional fusion protein that also catalyses EC 1.17.1.7, 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase.Combined the two activities result in a two-step conversion of oxepin-CoA to 3-oxo-5,6-dehydrosuberyl-CoA, part of an aerobic phenylacetate degradation pathway [1,3,4]. The enzyme from Escherichia coli also exhibits enoyl-CoA hydratase activity utilizing crotonyl-CoA as a substrate [2].
History
created 2011 as EC 3.7.1.16, transferred 2013 to EC 3.3.2.12
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1 Oxidoreductases
3 Hydrolases
3.3.2.1 isochorismatase
