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EC 3.3.2.7 Details
show Brenda entryEC number
3.3.2.7
Accepted name
hepoxilin-epoxide hydrolase
Reaction
hepoxilin A3 + H2O = trioxilin A3
Other name(s)
hepoxilin epoxide hydrolase,
hepoxylin hydrolase,
hepoxilin A3 hydrolase
Systematic name
(5Z,9E,14Z)-(8ξ,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase
CAS registry number
122096-98-4
Comment
Converts hepoxilin A3 into trioxilin A3. Highly specific for the substrate, having only slight activity with other epoxides such as leukotriene A4 and styrene oxide [2]. Hepoxilin A3 is an hydroxy-epoxide derivative of arachidonic acid that is formed via the 12-lipoxygenase pathway [2]. It is probable that this enzyme plays a modulatory role in inflammation, vascular physiology, systemic glucose metabolism and neurological function [4]. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) [3].
History
created 1992, modified 2006
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1 Oxidoreductases
3 Hydrolases
3.3.2.1 isochorismatase
