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6.4.1.4: methylcrotonoyl-CoA carboxylase

This is an abbreviated version!
For detailed information about methylcrotonoyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.4

Reaction

ATP
+
3-methylcrotonoyl-CoA
 +
HCO3-
 +
H+
=
ADP
 +
phosphate
 +
3-methylglutaconyl-CoA

Synonyms

3-MCC, 3-methylcrotonyl CoA carboxylase, 3-methylcrotonyl coenzyme A carboxylase, 3-methylcrotonyl coenzyme-A carboxylase, 3-methylcrotonyl-CoA carboxylase, 3-methylcrotonyl-CoA:carbon-dioxide ligase (ADP-forming), 3-methylcrotonyl-coenzyme A, 3-methylcrotonyl-coenzyme A carboxylase, beta-MCC, beta-methylcrotonyl CoA carboxylase, beta-Methylcrotonyl coenzyme A carboxylase, beta-methylcrotonyl-CoA carboxylase, Carboxylase, methylcrotonyl coenzyme A, glutaconyl-CoA decarboxylase, glutaconyl-CoA:biotin carboxytransferase, liuB, liuD, MC-CoA carboxylase, Mcase, MCC, Mcc2, MCCA, MCCase, MCCB, MCCC, Methylcrotonyl coenzyme A carboxylase, methylcrotonyl-CoA carboxylase, Pa-MCCase, PaMCC

ECTree

     6 Ligases
         6.4 Forming carbon-carbon bonds
             6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
                6.4.1.4 methylcrotonoyl-CoA carboxylase

KM Value

KM Value on EC 6.4.1.4 - methylcrotonoyl-CoA carboxylase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.022
(2Z)-3-ethylcrotonoyl-CoA
-
-
0.138 - 0.225
(E)-crotonoyl-CoA
0.0098 - 31
3-methylcrotonoyl-CoA
0.074
3-methylcrotonyl-CoA
-
37°C, pH 8.0, recombinant enzyme
0.01 - 21
ATP
2.8
bicarbonate
-
experimental conditions not available
0.11
crotonoyl-CoA
-
-
0.0008 - 2.2
HCO3-
additional information
additional information
-
MCCase activity shows sigmoidal kinetics for all the substrates and non-Michaelis-Menten kinetics, overview
-