6.4.1.4: methylcrotonoyl-CoA carboxylase

This is an abbreviated version!
For detailed information about methylcrotonoyl-CoA carboxylase, go to the full flat file.

Word Map on EC 6.4.1.4

6.4.1.4

rrna

dna-dna

phosphatidylethanolamine

carboxylases

rod-shaped

chemotaxonomic

biotin-dependent

diphosphatidylglycerol

propionyl-coa

3-hydroxyisovaleric

polyphasic

gram-stain-negative

biotin-containing

acidurias

aminolipids

3-methylcrotonylglycine

non-motile

isovaleric

deep-sea-derived

propionyl

holocarboxylase

catalase-positive

biotinidase

oxidase-positive

sediminis

anteiso-c15:0

3-hydroxyisovalerylcarnitine

cyclo

gram-staining-negative

ubiquinone-10

methylcitric

xiamenensis

non-spore-forming

ll-diaminopimelic

3-methylglutaconyl-coa

biotin-responsive

apocarboxylases

weihai

hresims

biotin-deficient

rhodobacteraceae

agriculture

medicine

Reaction

Synonyms

3-MCC, 3-methylcrotonyl CoA carboxylase, 3-methylcrotonyl coenzyme A carboxylase, 3-methylcrotonyl coenzyme-A carboxylase, 3-methylcrotonyl-CoA carboxylase, 3-methylcrotonyl-CoA:carbon-dioxide ligase (ADP-forming), 3-methylcrotonyl-coenzyme A, 3-methylcrotonyl-coenzyme A carboxylase, beta-MCC, beta-methylcrotonyl CoA carboxylase, beta-Methylcrotonyl coenzyme A carboxylase, beta-methylcrotonyl-CoA carboxylase, Carboxylase, methylcrotonyl coenzyme A, glutaconyl-CoA decarboxylase, glutaconyl-CoA:biotin carboxytransferase, liuB, liuD, MC-CoA carboxylase, Mcase, MCC, Mcc2, MCCA, MCCase, MCCB, MCCC, Methylcrotonyl coenzyme A carboxylase, methylcrotonyl-CoA carboxylase, Pa-MCCase, PaMCC

ECTree

6 Ligases

6.4 Forming carbon-carbon bonds

6.4.1 Ligases that form carbon-carbon bonds (only sub-subclass identified to date)

6.4.1.4 methylcrotonoyl-CoA carboxylase

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Results	in table
3	Activating Compound
6504	AA Sequence
3	Application
1	CAS Registry Number
14	Cloned(Commentary)
35	Cofactor
4	Crystallization (Commentary)
608	Disease/ Diagnostics
1	Expression
4	General Information
2	General Stability
55	Inhibitors
5	kcat/KM [mM/s]
61	KM Value [mM]
20	Localization
75	Metals/Ions
66	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
236	Organism
5	Pathway
16	PDB ID
16	pH Optimum
2	pH Range
17	Protein Variants
26	Purification (Commentary)
3	Reaction
1	Reaction Type
68	Reference
45	Source Tissue
13	Specific Activity [micromol/min/mg]
4	Storage Stability
110	Substrates and Products (Substrate)
32	Subunits
66	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
7	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 6.4.1.4 - methylcrotonoyl-CoA carboxylase

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(2E)-3-ethylcrotonoyl-CoA

Bos taurus

competitive with respect to 3-methylcrotonoyl-CoA

1884

(2Z)-geranoyl-CoA

Bos taurus

competitive with respect to 3-methylcrotonoyl-CoA

1884

(E)-2-methyl-2-butenoyl-CoA

weak

acetoacetyl-CoA

ADP

ADP and phosphate inhibit enzyme activity in an additive mode

1894

ATP

Zea mays

1896

Avidin

Pseudomonas citronellolis

irreversible inhibition

1888

butanoyl-CoA

2 entries

iodoacetamide

Achromobacter sp.

3-methylcrotonoyl-CoA protects against inactivation

isobutanoyl-CoA

weak

KCl

Li+

Mg2+

n-hexanoyl-CoA

weak

Na+

NEM

p-hydroxymercuribenzoate

palmitoyl-CoA

25% inhibition

pentanoyl-CoA

weak

Phenylglyoxal

phosphate

ADP and phosphate inhibit enzyme activity in an additive mode

1894

propanoyl-CoA

Bos taurus

competitive with respect to 3-methylcrotonoyl-CoA

1884

streptavidin

Pisum sativum

1895

additional information

5 entries