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6.3.4.14: biotin carboxylase

This is an abbreviated version!
For detailed information about biotin carboxylase, go to the full flat file.

Word Map on EC 6.3.4.14

Reaction

ATP
+
[biotin carboxyl-carrier protein]-biotin-N6-L-lysine
 +
hydrogencarbonate-
=
ADP
 +
phosphate
 +
[biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine

Synonyms

ACC, AccA, AccBC, AccC, BC, biotin carboxylase, biotin carboxylase (component of acetyl CoA carboxylase), biotinoyl domain of acetyl-CoA carboxylase, BirA, Carboxylase, biotin, More, PC-beta

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.4 Other carbon-nitrogen ligases
                6.3.4.14 biotin carboxylase

Molecular Weight

Molecular Weight on EC 6.3.4.14 - biotin carboxylase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
49320
-
x * 49320, calculation from nucleotide sequence
50000
51000
58235
x * 60000, SDS-PAGE, x * 58235, calculated
58300
x * 58300, calculated
60000
x * 60000, SDS-PAGE, x * 58235, calculated
61500
x * 61500, sequence calculation, x * 65000, SDS-PAGE
63400
-
x * 63400, calculation from nucleotide sequence, protein composed of two domains, an N-terminal biotin carboxylase and a C-terminal biotin-carboxyl-carrier protein
64700
-
x * 64700, recombinant biotin carboxylase domain
65000
x * 61500, sequence calculation, x * 65000, SDS-PAGE
95000
-
gel filtration, analytical ultracentrifugation
additional information
-
X-ray model of the enzyme. Those amino acid residues believed to form part of the active site pocket include His209-Glu211, His236-Glu241, Glu276, Ile287-Glu296, and Arg338