6.3.4.14: biotin carboxylase

This is an abbreviated version!
For detailed information about biotin carboxylase, go to the full flat file.

Word Map on EC 6.3.4.14

6.3.4.14

carboxyltransferase

carboxylases

biotin-dependent

malonyl-coa

acetyl-coenzyme

propionyl-coa

carboxybiotin

6.4.1.2

biotin-carboxyl

biotin-containing

bicarbonate-dependent

biotin-binding

carboxyphosphate

transcarboxylase

mgatp-dependent

accases

atp-grasp

medicine

Reaction

[biotin carboxyl-carrier protein]-biotin-N6-L-lysine

[biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine

Synonyms

ACC, AccA, AccBC, AccC, BC, biotin carboxylase, biotin carboxylase (component of acetyl CoA carboxylase), biotinoyl domain of acetyl-CoA carboxylase, BirA, Carboxylase, biotin, More, PC-beta

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.4 Other carbon-nitrogen ligases

6.3.4.14 biotin carboxylase

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Results	in table
10	Activating Compound
47325	AA Sequence
2	Application
1	CAS Registry Number
54	Cloned(Commentary)
48	Cofactor
24	Crystallization (Commentary)
11	Disease/ Diagnostics
1	Expression
3	General Information
2	General Stability
6	IC50 Value
40	Inhibitors
12	kcat/KM [mM/s]
3	Ki Value [mM]
93	KM Value [mM]
9	Localization
56	Metals/Ions
23	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
341	Organism
6	Pathway
166	PDB ID
8	pH Optimum
1	Posttranslational Modification
53	Protein Variants
22	Purification (Commentary)
9	Reaction
1	Reaction Type
107	Reference
5	Source Tissue
5	Specific Activity [micromol/min/mg]
179	Substrates and Products (Substrate)
39	Subunits
49	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Stability [°C]
34	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 6.3.4.14 - biotin carboxylase

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[biotin carboxyl-carrier protein]-biotin-N6-L-lysine:hydrogencarbonate ligase (ADP-forming)

This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15, biotin---[biotin carboxyl-carrier protein] ligase. In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria). Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyses the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2, acetyl-CoA carboxylase).