6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase

This is an abbreviated version!
For detailed information about 5-formyltetrahydrofolate cyclo-ligase, go to the full flat file.

Reaction

Synonyms

5,10-methenyl-tetrahydrofolate synthetase, 5,10-Methenyltetrahydrofolate synthetase, 5,10-Methenyltetrahydropteroylglutamate synthetase, 5-CHO-THF cycloligase, 5-FCL, 5-Formyltetrahydrofolate cyclodehydrase, CH+-THF synthetase, Fau1p, Formyltetrahydrofolic cyclodehydrase, Methenyl THFS, Methenyl-THF synthetase, Methenyltetrahydrofolate synthetase, More, MTHFD1, MTHFS, N5-Formyltetrahydrofolic acid cyclodehydrase, Synthetase, methenyltetrahydrofolate, ygfA

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.3 Cyclo-ligases

                6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
4	Activating Compound
36539	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
16	Cofactor
4	Crystallization (Commentary)
470	Disease/ Diagnostics
1	Expression
5	General Information
4	General Stability
6	IC50 Value
49	Inhibitors
18	Ki Value [mM]
76	KM Value [mM]
15	Localization
27	Metals/Ions
19	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
48	Organism
1	Oxidation Stability
7	Pathway
12	PDB ID
11	pH Optimum
2	pH Range
2	pH Stability
38	Protein Variants
20	Purification (Commentary)
9	Reaction
7	Reaction Type
48	Reference
53	Source Tissue
20	Specific Activity [micromol/min/mg]
3	Storage Stability
98	Substrates and Products (Substrate)
15	Subunits
66	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
4	Temperature Stability [°C]
26	Turnover Number [1/s]

KI Value

print visible entries

print all entries

KI Value on EC 6.3.3.2 - 5-formyltetrahydrofolate cyclo-ligase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Ki Value Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.013

10-formylfolic acid

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.001

5-formyl,10-methyltetrahydrofolate

Mus musculus

-

at 37°C in 100 mM MES, pH 6.0

671619

0.0007

5-Formyltetrahydrohomofolate

Mus musculus

-

at 37°C in 100 mM MES, pH 6.0

671619

0.058

folic acid

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.0001

folic acid pentaglutamate

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.0017

folic acid triglutamate

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.009

lometrexol

Mus musculus

-

-

701907

0.006

LY309887

Mus musculus

-

-

701907

0.048

pemetrexed

Mus musculus

-

-

701907

2.12

phosphate

Mycoplasma pneumoniae

-

pH 6.0, 37°C, recombinant enzyme

663363

0.00003

[6R,S]-10-formyltetrahydrofolate triglutamate

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.0002

[6R,S]-10-formyltetrahydrohomofolate

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.005

[6R,S]-10-formyltetrahydropteroate

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.02

[6R,S]-5-formyl,10-methyltetrahydrofolateGlu3

Mus musculus

-

at 37°C in 100 mM MES, pH 6.0

671619

0.006

[6R,S]-5-formyl,11-methyltetrahydrohomofolate

Mus musculus

-

at 37°C in 100 mM MES, pH 6.0

671619

0.0007

[6R,S]-5-formyltetrahydrohomofolate

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740

0.00015

[6R]-10-formyltetrahydrofolate

2 entries

0.00015

[6R]-10-formyltetrahydrofolate

Mus musculus

-

-

701907

0.00015

[6R]-10-formyltetrahydrofolate

Homo sapiens

-

at 37°C in 100 mM MES, pH 6.0

674740