6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase

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For detailed information about 5-formyltetrahydrofolate cyclo-ligase, go to the full flat file.

Word Map on EC 6.3.3.2

6.3.3.2

mthfr

methylenetetrahydrofolate

one-carbon

homocysteine

folate-dependent

slc19a1

10-formyltetrahydrofolate

trifunctional

cyclohydrolase

5,10-methylenetetrahydrofolate

remethylation

folate-mediated

folate-related

1-carbon

megaloblastic

periconceptional

folate-metabolizing

analysis

pharmacology

medicine

Reaction

Synonyms

5,10-methenyl-tetrahydrofolate synthetase, 5,10-Methenyltetrahydrofolate synthetase, 5,10-Methenyltetrahydropteroylglutamate synthetase, 5-CHO-THF cycloligase, 5-FCL, 5-Formyltetrahydrofolate cyclodehydrase, CH+-THF synthetase, Fau1p, Formyltetrahydrofolic cyclodehydrase, Methenyl THFS, Methenyl-THF synthetase, Methenyltetrahydrofolate synthetase, More, MTHFD1, MTHFS, N5-Formyltetrahydrofolic acid cyclodehydrase, Synthetase, methenyltetrahydrofolate, ygfA

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.3 Cyclo-ligases

6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

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Results	in table
4	Activating Compound
36539	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
16	Cofactor
4	Crystallization (Commentary)
470	Disease/ Diagnostics
1	Expression
5	General Information
4	General Stability
6	IC50 Value
49	Inhibitors
18	Ki Value [mM]
76	KM Value [mM]
15	Localization
27	Metals/Ions
19	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
48	Organism
1	Oxidation Stability
7	Pathway
12	PDB ID
11	pH Optimum
2	pH Range
2	pH Stability
38	Protein Variants
20	Purification (Commentary)
9	Reaction
7	Reaction Type
48	Reference
53	Source Tissue
20	Specific Activity [micromol/min/mg]
3	Storage Stability
98	Substrates and Products (Substrate)
15	Subunits
66	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
4	Temperature Stability [°C]
26	Turnover Number [1/s]

Oxidation Stability

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Oxidation Stability on EC 6.3.3.2 - 5-formyltetrahydrofolate cyclo-ligase

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rapid loss of activity unless kept in the presence of reducing agents, e.g. DTT

Lacticaseibacillus casei

1320