6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase

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For detailed information about 5-formyltetrahydrofolate cyclo-ligase, go to the full flat file.

Word Map on EC 6.3.3.2

6.3.3.2

mthfr

methylenetetrahydrofolate

one-carbon

homocysteine

folate-dependent

slc19a1

10-formyltetrahydrofolate

trifunctional

cyclohydrolase

5,10-methylenetetrahydrofolate

remethylation

folate-mediated

folate-related

1-carbon

megaloblastic

periconceptional

folate-metabolizing

analysis

pharmacology

medicine

Reaction

Synonyms

5,10-methenyl-tetrahydrofolate synthetase, 5,10-Methenyltetrahydrofolate synthetase, 5,10-Methenyltetrahydropteroylglutamate synthetase, 5-CHO-THF cycloligase, 5-FCL, 5-Formyltetrahydrofolate cyclodehydrase, CH+-THF synthetase, Fau1p, Formyltetrahydrofolic cyclodehydrase, Methenyl THFS, Methenyl-THF synthetase, Methenyltetrahydrofolate synthetase, More, MTHFD1, MTHFS, N5-Formyltetrahydrofolic acid cyclodehydrase, Synthetase, methenyltetrahydrofolate, ygfA

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.3 Cyclo-ligases

6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

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Results	in table
4	Activating Compound
36539	AA Sequence
4	Application
1	CAS Registry Number
19	Cloned(Commentary)
16	Cofactor
4	Crystallization (Commentary)
470	Disease/ Diagnostics
1	Expression
5	General Information
4	General Stability
6	IC50 Value
49	Inhibitors
18	Ki Value [mM]
76	KM Value [mM]
15	Localization
27	Metals/Ions
19	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
48	Organism
1	Oxidation Stability
7	Pathway
12	PDB ID
11	pH Optimum
2	pH Range
2	pH Stability
38	Protein Variants
20	Purification (Commentary)
9	Reaction
7	Reaction Type
48	Reference
53	Source Tissue
20	Specific Activity [micromol/min/mg]
3	Storage Stability
98	Substrates and Products (Substrate)
15	Subunits
66	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
4	Temperature Stability [°C]
26	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 6.3.3.2 - 5-formyltetrahydrofolate cyclo-ligase

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0.00006

Oryctolagus cuniculus

placenta

649293

0.00026

Oryctolagus cuniculus

postweaning, brain

649293

0.00032

Oryctolagus cuniculus

kidney

649293

0.00036

Oryctolagus cuniculus

fetal liver

649293

0.0011

Oryctolagus cuniculus

adult liver

649293

0.0015

Oryctolagus cuniculus

3 weeks old liver

649293

Oryctolagus cuniculus

1331

2.22

Mus musculus

Q9D110

purified recombinant enzyme

663298

2.8

Mycoplasma pneumoniae

purified recombinant enzyme

663363

3.8

Lacticaseibacillus casei

1320, 1322

Homo sapiens

1319

Saccharomyces cerevisiae

purified recombinant enzyme

652260

additional information

8 entries