6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase
This is an abbreviated version!
For detailed information about 5-formyltetrahydrofolate cyclo-ligase, go to the full flat file.
Word Map on EC 6.3.3.2
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6.3.3.2
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mthfr
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methylenetetrahydrofolate
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one-carbon
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homocysteine
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folate-dependent
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slc19a1
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10-formyltetrahydrofolate
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trifunctional
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cyclohydrolase
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5,10-methylenetetrahydrofolate
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remethylation
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folate-mediated
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folate-related
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1-carbon
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megaloblastic
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periconceptional
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folate-metabolizing
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analysis
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pharmacology
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medicine
- 6.3.3.2
- mthfr
- methylenetetrahydrofolate
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one-carbon
- homocysteine
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folate-dependent
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slc19a1
- 10-formyltetrahydrofolate
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trifunctional
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cyclohydrolase
- 5,10-methylenetetrahydrofolate
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remethylation
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folate-mediated
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folate-related
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1-carbon
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megaloblastic
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periconceptional
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folate-metabolizing
- analysis
- pharmacology
- medicine
Reaction
Synonyms
5,10-methenyl-tetrahydrofolate synthetase, 5,10-Methenyltetrahydrofolate synthetase, 5,10-Methenyltetrahydropteroylglutamate synthetase, 5-CHO-THF cycloligase, 5-FCL, 5-Formyltetrahydrofolate cyclodehydrase, CH+-THF synthetase, Fau1p, Formyltetrahydrofolic cyclodehydrase, Methenyl THFS, Methenyl-THF synthetase, Methenyltetrahydrofolate synthetase, More, MTHFD1, MTHFS, N5-Formyltetrahydrofolic acid cyclodehydrase, Synthetase, methenyltetrahydrofolate, ygfA
ECTree
6.3.3.2 5-formyltetrahydrofolate cyclo-ligaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 6.3.3.2 - 5-formyltetrahydrofolate cyclo-ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 5-formyltetrahydrofolate
?
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obligatory initial metabolic step in the intracellular conversion of 5-formyltetrahydrofolate to other reduced folates
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?
ATP + 5-formyltetrahydrofolate
?
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it is proposed that methenyltetrahydrofolate synthetase is a salvage enzyme which converts the nonenzymatically formed and nonmetabolically active 5-formyltetrahydropteroyl-(Glu)n back into the one-carbon donor folate pool. It is also possible that methenyltetrahydrofolate synthetase is part of a regulation system in the cell in which its substrate 5-formyl-tetrahydropteroyl-(Glu)n plays a role as a regulator of one-carbon metabolism by inhibiting other folate requiring enzymes
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?
ATP + 5-formyltetrahydrofolate
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key enzymatic reaction in the pathway by which 5-formyltetrahydrofolate enters the folate coenzyme pool
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?
ATP + 5-formyltetrahydrofolate
ADP + 5,10-methenyltetrahydrofolate + phosphate
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recycling reaction
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?
ATP + 5-formyltetrahydrofolate
ADP + 5,10-methenyltetrahydrofolate + phosphate
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important reaction in one-carbon donor recycling
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?
ATP + 5-formyltetrahydrofolate
ADP + 5,10-methenyltetrahydrofolate + phosphate
the enzyme affects intracellular folate concentrations by accelerating folate degradation
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?
ATP + 5-formyltetrahydrofolate
ADP + 5,10-methenyltetrahydrofolate + phosphate
the enzyme affects intracellular folate concentrations by accelerating folate degradation
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?
ATP + 5-formyltetrahydrofolate
ADP + 5,10-methenyltetrahydrofolate + phosphate
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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ir
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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-
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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-
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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enzyme plays an important role in one-carbon metabolism, overview about folate catabolism
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ir
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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-
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-
?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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-
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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enzyme plays a central role in the regulation of folate-dependent, one-carbon metabolism
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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?
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
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ir
additional information
?
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increased MTHFS expression affects the efficacy of the glycinamide ribonucleotide formyltransferase inhibitor LY309887, overview. SH-SY5Y neuroblastoma with increased MTHFS expression display a 4fold resistance to the GARFT inhibitor LY309887, but do not exhibit resistance to the thymidylate synthase inhibitor Pemetrexed.
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?
additional information
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disruption of folate metabolism is associated with several pathologies and developmental anomalies including cancer and neural tube defects
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?
additional information
?
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disruption of folate metabolism is associated with several pathologies and developmental anomalies including cancer and neural tube defects
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?
additional information
?
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disruption of folate metabolism is associated with several pathologies and developmental anomalies including cancer and neural tube defects
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?
