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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase is significantly upregulated in the liquid surface culture compared to submerged culture
regulation of both phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), and of pyruvate kinase activity, by L-glutamine, a co-substrate for PPAT. A glutamine antagonist, 6-diazo-5-oxo-L-norleucine (DON) blocks glutamine mediated induction of PPAT and PAICS as well as reduced pyruvate kinase activity, which is completely reversible by addition of L-glutamate
phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase is significantly upregulated in the liquid surface culture compared to submerged culture
phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase is significantly upregulated in the liquid surface culture compared to submerged culture