phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) is an important bifunctional enzyme in de novo purine biosynthesis in vertebrate with both 5-aminoimidazole ribonucleotide carboxylase (AIRc) and 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase (SAICARs) activities. It is an attractive target for rational anticancer drug design, since rapidly dividing cancer cells rely heavily on the purine de novo pathway for synthesis of adenine and guanine, whereas normal cells favor the salvage pathway
4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase (PurC) is an ideal target for the discovery of antimicrobials against the pathogen
4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase (PurC) is an ideal target for the discovery of antimicrobials against the pathogen
4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase (PurC) is an ideal target for the discovery of antimicrobials against the pathogen