6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase

This is an abbreviated version!
For detailed information about phosphoribosylaminoimidazolesuccinocarboxamide synthase, go to the full flat file.

Word Map on EC 6.3.2.6

6.3.2.6

purine

carboxylase

paics

ribotide

adenylosuccinate

4.1.1.21

horikoshii

drug development

medicine

Reaction

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

Synonyms

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase, 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase, 5-Aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase, ade5, AIRc-SAICARs, ATPase, BaPurC, CCM_04437, MjSS, More, N-(5-Amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5�-phosphate synthetase, PAICS, PH0239, PH0239 protein, phosphoribosylaminoimidazole succinocarboxamide synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, phosphoribosylaminoimidazole-succinocarboxamide synthetase, Phosphoribosylaminoimidazolesuccinocarboxamide synthetase, PhSS, PurC, PurC gene product, PurCE, SAICAR synthase, SAICAR synthetase, spPurC, Succino-AICAR synthetase, Synthetase, phosphoribosylaminoimidazolesuccinocarboxamide, VEG286A, Vegetative protein 286A

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase

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Results	in table
43893	AA Sequence
4	Application
1	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
13	Crystallization (Commentary)
20	Disease/ Diagnostics
3	Expression
25	General Information
2	General Stability
5	Inhibitors
15	Ki Value [mM]
4	KM Value [mM]
14	Metals/Ions
15	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
50	Organism
8	Pathway
67	PDB ID
3	pH Optimum
1	pH Stability
14	Purification (Commentary)
1	Reaction
2	Reaction Type
48	Reference
20	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
27	Subunits
84	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
5	Temperature Stability [°C]

Purification

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Purification on EC 6.3.2.6 - phosphoribosylaminoimidazolesuccinocarboxamide synthase

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4 entries

ammonium sulfate, DEAE-Sephadex, Butyl-Toyopearl

Saccharomyces cerevisiae

P27616

653921

copurification of EC 4.1.1.21/EC 6.3.2.6

Gallus gallus

1263

copurification of the bifunctional protein complex possessing phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (EC 6.3.2.6)

Ovis aries

1266

partial

Pigeon

1403

recombinant His-tagged enzyme from Escherichia coli strain BL21-CodonPlus (DE3)-RIL by nickel affinity chromatography and gel filtration

2 entries

recombinant His-tagged enzyme from Escherichia coli strain BL21-Gold by nickel affinity chromatography and gel filtration

Streptococcus pneumoniae

743939

recombinant His-tagged enzyme from insect HighFive cells by nickel affinity and anion exchange chromatography, followed by gel filtration

recombinant protein