6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase This is an abbreviated version! For detailed information about phosphoribosylaminoimidazolesuccinocarboxamide synthase, go to the full flat file .
Reaction
ATP +
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate +
L-aspartate =
ADP +
phosphate +
(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
Synonyms 4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase, 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase, 5-Aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase, ade5, AIRc-SAICARs, ATPase, BaPurC, CCM_04437, MjSS, More, N-(5-Amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5´-phosphate synthetase, PAICS, PH0239, PH0239 protein, phosphoribosylaminoimidazole succinocarboxamide synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, phosphoribosylaminoimidazole-succinocarboxamide synthetase, Phosphoribosylaminoimidazolesuccinocarboxamide synthetase, PhSS, PurC, PurC gene product, PurCE, SAICAR synthase, SAICAR synthetase, spPurC, Succino-AICAR synthetase, Synthetase, phosphoribosylaminoimidazolesuccinocarboxamide, VEG286A, Vegetative protein 286A
ECTree
Subunits
Subunits on EC 6.3.2.6 - phosphoribosylaminoimidazolesuccinocarboxamide synthase
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monomer
structure overview
oligomer
-
x * 50000, SDS-PAGE
trimer
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3 * 27000, SDS-PAGE
?
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x * 27431, calculation from nucleotide sequence
?
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x * 26998, calculation from nucleotide sequence
?
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x * 35500, calculation from crystallographic data and X-ray diffraction
?
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x * 26600, calculated
dimer
2 * 29701, sequence calculation, 2 * 29569, mass spectrometry
dimer
-
structure overview, PDB ID 2GQS
dimer
2 * 29166, sequence calculation, 2 * 29035, mass spectrometry
dimer
-
2 * 29166, sequence calculation, 2 * 29035, mass spectrometry
-
dimer
-
structure overview
octamer
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the 2.8 A resolution structure reveals that eight PAICS subunits, each composed of distinct AIRc and SAICARs domains, assemble a compact homo-octamer with an octameric-carboxylase core and four symmetric periphery dimers formed by synthetase domains
octamer
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4 dimers of PurC around a core of octameric PurE, the PurC dimers do not contact each other, structure overview, PDB ID 2H31
additional information
modeling of the quaternary structure of dimeric enzyme BaPurC, based on the dimer structure of Streptococcus pneumoniae SpPurC, PDB ID 4FE2
additional information
-
modeling of the quaternary structure of dimeric enzyme BaPurC, based on the dimer structure of Streptococcus pneumoniae SpPurC, PDB ID 4FE2
additional information
analysis of the dimer structure of enzyme SpPurC, PDB ID 4FE2
additional information
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analysis of the dimer structure of enzyme SpPurC, PDB ID 4FE2
additional information
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analysis of the dimer structure of enzyme SpPurC, PDB ID 4FE2
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additional information
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structure modeling, overview