6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase

This is an abbreviated version!
For detailed information about phosphoribosylaminoimidazolesuccinocarboxamide synthase, go to the full flat file.

Reaction

Synonyms

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase, 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase, 5-Aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase, ade5, AIRc-SAICARs, ATPase, BaPurC, CCM_04437, MjSS, More, N-(5-Amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5�-phosphate synthetase, PAICS, PH0239, PH0239 protein, phosphoribosylaminoimidazole succinocarboxamide synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, phosphoribosylaminoimidazole-succinocarboxamide synthetase, Phosphoribosylaminoimidazolesuccinocarboxamide synthetase, PhSS, PurC, PurC gene product, PurCE, SAICAR synthase, SAICAR synthetase, spPurC, Succino-AICAR synthetase, Synthetase, phosphoribosylaminoimidazolesuccinocarboxamide, VEG286A, Vegetative protein 286A

ECTree

     6 Ligases

         6.3 Forming carbon-nitrogen bonds

             6.3.2 Acid—amino-acid ligases (peptide synthases)

                6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase

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Results	in table
43893	AA Sequence
4	Application
1	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
13	Crystallization (Commentary)
20	Disease/ Diagnostics
3	Expression
25	General Information
2	General Stability
5	Inhibitors
15	Ki Value [mM]
4	KM Value [mM]
14	Metals/Ions
15	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
50	Organism
8	Pathway
67	PDB ID
3	pH Optimum
1	pH Stability
14	Purification (Commentary)
1	Reaction
2	Reaction Type
48	Reference
20	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
27	Subunits
84	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
5	Temperature Stability [°C]

Disease

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Disease on EC 6.3.2.6 - phosphoribosylaminoimidazolesuccinocarboxamide synthase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Adenocarcinoma of Lung

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.

26140362

Carcinogenesis

Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.

30097015

Neoplasm Metastasis

PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer.

32218208

Neoplasms

Determinants of the toxicity of L-alanosine to various organs of the mouse.

7281196

Neoplasms

PAICS contributes to gastric carcinogenesis and participates in DNA damage response by interacting with histone deacetylase 1/2.

32632107

Prostatic Neoplasms

Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer.

27550065

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