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EC Number Application Commentary Reference
Show all pathways known for 6.3.2.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.6drug development 4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase (PurC) is an ideal target for the discovery of antimicrobials against the pathogen -, 746369
Show all pathways known for 6.3.2.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.6medicine phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) is an important bifunctional enzyme in de novo purine biosynthesis in vertebrate with both 5-aminoimidazole ribonucleotide carboxylase (AIRc) and 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase (SAICARs) activities. It is an attractive target for rational anticancer drug design, since rapidly dividing cancer cells rely heavily on the purine de novo pathway for synthesis of adenine and guanine, whereas normal cells favor the salvage pathway 675427
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