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EC Number Expression Commentary Reference
Show all pathways known for 6.3.2.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.6up phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase is significantly upregulated in the liquid surface culture compared to submerged culture -, 746228
Show all pathways known for 6.3.2.6Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.6up regulation of both phosphoribosyl amidotransferase (PPAT) and phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), and of pyruvate kinase activity, by L-glutamine, a co-substrate for PPAT. A glutamine antagonist, 6-diazo-5-oxo-L-norleucine (DON) blocks glutamine mediated induction of PPAT and PAICS as well as reduced pyruvate kinase activity, which is completely reversible by addition of L-glutamate 745942
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