5.4.3.2: lysine 2,3-aminomutase

This is an abbreviated version!
For detailed information about lysine 2,3-aminomutase, go to the full flat file.

Word Map on EC 5.4.3.2

Reaction

L-lysine
=
(3S)-3,6-diaminohexanoate

Synonyms

Aminomutase, lysine 2,3-, Mutase, lysine 2,3-amino-, L-Lysine-2,3-aminomutase, LAM, KAM, lysine 2,3-aminomutase, lysine-2,3-aminomutase, AblA, YjeK, kamA, HD73_2540

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.3 Transferring amino groups
                5.4.3.2 lysine 2,3-aminomutase

Activating Compound

Activating Compound on EC 5.4.3.2 - lysine 2,3-aminomutase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Dithionite
activity absolutely depends on the addition of dithionite
ethylamine
-
saturating ethylamine accelerates the L-alanine reaction 70fold
Ferredoxin
-
enzyme activity is dependent on the presence of flavodoxin, ferredoxin, or flavodoxin-NADP+ reductase
-
flavodoxin
-
enzyme activity is dependent on the presence of flavodoxin, ferredoxin, or flavodoxin-NADP+ reductase
-
L-cysteine
-
required for in vitro activity
methylamine
-
saturating methylamine accelerates the L-2-aminobutyrate reaction 47fold
pyridoxal 5'-phosphate
-
required for in vitro activity
Reducing agent
-
required
-
S-adenosyl-L-methionine
S-adenosylmethionine
Sodium dithionite
-
required for in vitro activity
sulfhydryl compound
-
can reactivate oxygen-inactivated enzyme, optimal activation when 0.9 mM Fe2+ is present