5.4.3.2: lysine 2,3-aminomutase

This is an abbreviated version!
For detailed information about lysine 2,3-aminomutase, go to the full flat file.

Word Map on EC 5.4.3.2

5.4.3.2

s-adenosylmethionine

5\'-deoxyadenosyl

epr

pyridoxal

l-beta-lysine

hyperfine

adenosylcobalamin-dependent

formate-lyase

subterminale

aldimine

pyridoxal-5'-phosphate

adenosylcobalamin

5'-deoxyadenosine

cxxxcxxc

homolytic

deoxyadenosyl

aminomutases

synthesis

Reaction

Synonyms

AblA, Aminomutase, lysine 2,3-, HD73_2540, KAM, kamA, L-Lysine-2,3-aminomutase, LAM, lysine 2,3-aminomutase, lysine-2,3-aminomutase, Mutase, lysine 2,3-amino-, YjeK

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.3 Transferring amino groups

5.4.3.2 lysine 2,3-aminomutase

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Results	in table
35	Activating Compound
4141	AA Sequence
6	Application
1	CAS Registry Number
11	Cloned(Commentary)
43	Cofactor
1	Crystallization (Commentary)
5	Expression
28	General Information
16	Inhibitors
1	kcat/KM [mM/s]
3	KM Value [mM]
36	Metals/Ions
11	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
240	Organism
3	Oxidation Stability
5	Pathway
4	PDB ID
2	pH Optimum
1	pH Range
25	Protein Variants
13	Purification (Commentary)
24	Reaction
3	Reaction Type
74	Reference
8	Specific Activity [micromol/min/mg]
2	Storage Stability
95	Substrates and Products (Substrate)
18	Subunits
40	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 5.4.3.2 - lysine 2,3-aminomutase

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L-lysine 2,3-aminomutase

This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule. Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions. A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron-sulfur cluster. S-adenosyl-L-methionine is regenerated at the end of the reaction.