5.4.3.2: lysine 2,3-aminomutase

This is an abbreviated version!
For detailed information about lysine 2,3-aminomutase, go to the full flat file.

Word Map on EC 5.4.3.2

Reaction

L-lysine
=
(3S)-3,6-diaminohexanoate

Synonyms

Aminomutase, lysine 2,3-, Mutase, lysine 2,3-amino-, L-Lysine-2,3-aminomutase, LAM, KAM, lysine 2,3-aminomutase, lysine-2,3-aminomutase, AblA, YjeK, kamA, HD73_2540

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.3 Transferring amino groups
                5.4.3.2 lysine 2,3-aminomutase

Systematic Name

Systematic Name on EC 5.4.3.2 - lysine 2,3-aminomutase

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SYSTEMATIC NAME
IUBMB Comments
L-lysine 2,3-aminomutase
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule. Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions. A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron-sulfur cluster. S-adenosyl-L-methionine is regenerated at the end of the reaction.