5.4.3.2: lysine 2,3-aminomutase

This is an abbreviated version!
For detailed information about lysine 2,3-aminomutase, go to the full flat file.

Word Map on EC 5.4.3.2

Reaction

L-lysine
=
(3S)-3,6-diaminohexanoate

Synonyms

Aminomutase, lysine 2,3-, Mutase, lysine 2,3-amino-, L-Lysine-2,3-aminomutase, LAM, KAM, lysine 2,3-aminomutase, lysine-2,3-aminomutase, AblA, YjeK, kamA, HD73_2540

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.3 Transferring amino groups
                5.4.3.2 lysine 2,3-aminomutase

Engineering

Engineering on EC 5.4.3.2 - lysine 2,3-aminomutase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D172N
no catalytic activity, 0.43 mol iron and 0.13 mol sulfur per mol of subunit
R134Q
no catalytic activity, 2.8 mol iron and 2.7 mol sulfur per mol of subunit. Involved in binding of epsilon-aminium and alpha-carboxylate groups of substrate
D96N
less than 1% of wild-type activity, 1.2 mol iron and 0.95 mol sulfur per mol of subunit
D293N
no catalytic activity, 0.97 mol iron and 0.05 mol sulfur per mol of subunit. Involved in binding of epsilon-aminium and alpha-carboxylate groups of substrate
D165N
about 0.1% of wild-type activity, 0.23 mol iron and 0.13 mol sulfur per mol of subunit
R130Q
no catalytic activity, 0.42 mol iron and 0.2 mol sulfur per mol of subunit
E86Q
about 20% of wild-type activity, 0.5 mol iron and 0.4 mol sulfur per mol of subunit
R135K
about 16% of wild-type activity, 2.4 mol iron and 1.6 mol sulfur per mol of subunit
D330A
no catalytic activity, 1.9 mol iron and 1.3 mol sulfur per mol of subunit. Involved in binding of epsilon-aminium and alpha-carboxylate groups of substrate
R134K
no catalytic activity, 1.5 mol iron and 1.5 mol sulfur per mol of subunit
E236Q
about 1% of wild-type activity, 0.7 mol iron and 0.5 mol sulfur per mol of subunit
D330N
no catalytic activity, 1.0 mol iron and 0.63 mol sulfur per mol of subunit
R130K
no catalytic activity, 0.2 mol iron and 0.3 mol sulfur per mol of subunit
R135Q
about 1.5% of wild-type activity, 1.8 mol iron and 1.5 mol sulfur per mol of subunit
R136Q
about 1.2% of wild-type activity, 0.48 mol iron and 0.35 mol sulfur per mol of subunit
D172N
-
no catalytic activity, 0.43 mol iron and 0.13 mol sulfur per mol of subunit
-
R134Q
-
no catalytic activity, 2.8 mol iron and 2.7 mol sulfur per mol of subunit. Involved in binding of epsilon-aminium and alpha-carboxylate groups of substrate
-
D96N
-
less than 1% of wild-type activity, 1.2 mol iron and 0.95 mol sulfur per mol of subunit
-
D293N
-
no catalytic activity, 0.97 mol iron and 0.05 mol sulfur per mol of subunit. Involved in binding of epsilon-aminium and alpha-carboxylate groups of substrate
-
D165N
-
about 0.1% of wild-type activity, 0.23 mol iron and 0.13 mol sulfur per mol of subunit
-
DELTAabl::pac
-
deletion mutant, loss of the ability to synthesise Nepsilon-acetyl-beta-lysine
additional information