5.4.3.2: lysine 2,3-aminomutase

This is an abbreviated version!
For detailed information about lysine 2,3-aminomutase, go to the full flat file.

Word Map on EC 5.4.3.2

Reaction

L-lysine
=
(3S)-3,6-diaminohexanoate

Synonyms

Aminomutase, lysine 2,3-, Mutase, lysine 2,3-amino-, L-Lysine-2,3-aminomutase, LAM, KAM, lysine 2,3-aminomutase, lysine-2,3-aminomutase, AblA, YjeK, kamA, HD73_2540

ECTree

     5 Isomerases
         5.4 Intramolecular transferases
             5.4.3 Transferring amino groups
                5.4.3.2 lysine 2,3-aminomutase

Inhibitors

Inhibitors on EC 5.4.3.2 - lysine 2,3-aminomutase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4,5-dehydro-(S)-lysine
-
suicide inactivator
4-thia-L-lysine
-
substrate analogue, generates a stable analogues of the alpha-Lys radical
Co2+
-
0.1 mM, 80% inhibition
Fe2+
-
in a [4Fe-4S] cluster
iodoacetic acid
-
-
S-adenosylhomocysteine
-
competitive towards S-adenosylmethionine
S-aminoethylcysteine
-
-
SDS
-
50 mM, the rate of inactivation decreases in the presence of L-Lys, S-adenosylmethionine or S-adenosylhomocysteine. The SDS-dissociated enzyme can be slightly reactivated by removal of the detergent by gel filtration or dialysis
trans-4,5-dehydro-L-lysine
Urea
-
4 M