5.2.1.2: maleylacetoacetate isomerase

This is an abbreviated version!
For detailed information about maleylacetoacetate isomerase, go to the full flat file.

Reaction

Synonyms

AtGSTZ1, AtMAAI, glutathione S-transferase Zeta 1-1, glutathione S-transferase zeta-class 1, glutathione S-transferase zeta/maleylacetoacetate isomerase, glutathione transferase zeta, glutathione transferase zeta 1/maleylacetoacetate isomerase, Gstz1, GSTZ1-1, GSTz1/MAAI, GSTzeta/MAAI, Isomerase, maleylacetoacetate, MAAI, MAc-tI, maleylacetoacetate isomerase, Maleylacetoacetic isomerase, Maleylacetone cis-trans-isomerase, Maleylacetone isomerase, More

ECTree

     5 Isomerases

         5.2 cis-trans-Isomerases

             5.2.1 cis-trans Isomerases (only sub-subclass identified to date)

                5.2.1.2 maleylacetoacetate isomerase

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Results	in table
10	Activating Compound
6201	AA Sequence
3	Application
1	CAS Registry Number
4	Cloned(Commentary)
2	Crystallization (Commentary)
126	Disease/ Diagnostics
3	General Information
1	General Stability
16	Inhibitors
21	KM Value [mM]
3	Localization
8	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
41	Organism
7	Pathway
20	PDB ID
2	pH Optimum
1	pH Range
5	Protein Variants
4	Purification (Commentary)
4	Reaction
3	Reaction Type
33	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
5	Subunits
29	Synonyms
1	Systematic Name
18	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 5.2.1.2 - maleylacetoacetate isomerase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(3Z)-1,3-butadiene-1,1,2,4-tetrol

Homo sapiens

O43708

competitive inhibitor identified by rational design, calculated to be no substrate and not inhibitory to CYP450 and nontoxic in AMES test

747224

(Z)-3-[4-hydroxy-1-(hydroxymethyl)cyclohexyl]-2-propene-1,2-diol

Homo sapiens

O43708

competitive inhibitor identified by rational design, calculated to be no substrate and not inhibitory to CYP450 and nontoxic in AMES test

747224

Dichloroacetate

Homo sapiens

-

the sensitivity to the inhibitor varies between enzyme haplotypes. Three nonsynonymous single-nucleotide polymorphisms of GSTz1/MAAI show different activity toward dichloroacetate and certain other xenobiotic haloacids

728222

Dichloroacetic acid

Mus musculus

-

DCA

702157

GSSG

Vibrio sp.

-

-

2463, 2471

iodoacetate

Vibrio sp.

-

-

2465

maleylacetone

Vibrio sp.

-

inhibits isomerization of 6-oxo-2(E),4(Z)-heptanedienoic acid into 6-oxo-2(Z),4(E)-heptanedienoic acid, and the reverse reaction

2460

N-Hexylmaleamic acid

Vibrio sp.

-

noncompetitive towards GSH and maleylacetone

2471

NaBH4

Vibrio sp.

-

inhibition in absence of substrate, increases activity in presence of substrate and GSH

2465

NEM

2 entries

S-Glutathioyl-N-hexylmaleamate

Vibrio sp.

-

competitive towards GSH, uncompetitive towards maleylacetone

2471

S-Methylglutathione

Vibrio sp.

-

-

2463, 2471

NEM

Vibrio sp.

-

biphasic kinetics

2461

NEM

Vibrio sp.

-

-

2465, 2471