5.2.1.2: maleylacetoacetate isomerase
This is an abbreviated version!
For detailed information about maleylacetoacetate isomerase, go to the full flat file.
Word Map on EC 5.2.1.2
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5.2.1.2
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dichloroacetate
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fumarylacetoacetate
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dca-induced
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succinylacetone
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chlorofluoroacetic
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homogentisate
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tyrosinemia
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medicine
- 5.2.1.2
- dichloroacetate
- fumarylacetoacetate
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dca-induced
- succinylacetone
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chlorofluoroacetic
- homogentisate
- tyrosinemia
- medicine
Reaction
Synonyms
AtGSTZ1, AtMAAI, glutathione S-transferase Zeta 1-1, glutathione S-transferase zeta-class 1, glutathione S-transferase zeta/maleylacetoacetate isomerase, glutathione transferase zeta, glutathione transferase zeta 1/maleylacetoacetate isomerase, Gstz1, GSTZ1-1, GSTz1/MAAI, GSTzeta/MAAI, Isomerase, maleylacetoacetate, MAAI, MAc-tI, maleylacetoacetate isomerase, Maleylacetoacetic isomerase, Maleylacetone cis-trans-isomerase, Maleylacetone isomerase, More
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Natural Substrates Products on EC 5.2.1.2 - maleylacetoacetate isomerase
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REACTION DIAGRAM
Maleylacetoacetate
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human maleylacetoacetate isomerase deficiency presumably causes tyrosinemia that can be characterized by the absence of succinylacetone
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Maleylacetoacetate
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enzymatic isomerization of cis,cis-muconaldehydic acid to trans,trans-muconaldehydic acid followed by the oxidation is suggested to be the path to trans,trans-muconate
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Maleylacetoacetate
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one of the enzymes responsible for the oxidative metabolism of aromatic amino acids
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enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone
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additional information
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enzyme deficiency would presumably cause tyrosinemia that would be characterized by the absence of succinylacetone
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additional information
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key enzyme in the metabolic degradation of phenylalanine and tyrosine
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additional information
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key enzyme in the metabolic degradation of phenylalanine and tyrosine
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additional information
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the enzyme plays an important role in the metabolism of tyrosine
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additional information
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GSTzeta/MAAI is induced during the differentiation of 3T3-L1 fibroblasts into adipocytes. This process requires expression of C/EBPalpha as well as PPARgamma
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additional information
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the enzyme catalyzes the penultimate step in catabolic pathways for phenylalanine and tyrosine. BABL/c GSTZ1/MAAI-deficient mice show a number of significant abnormalities including altered organ sizes, an abnormal pattern of circulating leukocytes, and the consitutive induction of hepatic alpha, mu and pi class glutathione transferases
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