5.2.1.2: maleylacetoacetate isomerase

This is an abbreviated version!
For detailed information about maleylacetoacetate isomerase, go to the full flat file.

Reaction

Synonyms

AtGSTZ1, AtMAAI, glutathione S-transferase Zeta 1-1, glutathione S-transferase zeta-class 1, glutathione S-transferase zeta/maleylacetoacetate isomerase, glutathione transferase zeta, glutathione transferase zeta 1/maleylacetoacetate isomerase, Gstz1, GSTZ1-1, GSTz1/MAAI, GSTzeta/MAAI, Isomerase, maleylacetoacetate, MAAI, MAc-tI, maleylacetoacetate isomerase, Maleylacetoacetic isomerase, Maleylacetone cis-trans-isomerase, Maleylacetone isomerase, More

ECTree

     5 Isomerases

         5.2 cis-trans-Isomerases

             5.2.1 cis-trans Isomerases (only sub-subclass identified to date)

                5.2.1.2 maleylacetoacetate isomerase

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Results	in table
10	Activating Compound
6201	AA Sequence
3	Application
1	CAS Registry Number
4	Cloned(Commentary)
2	Crystallization (Commentary)
126	Disease/ Diagnostics
3	General Information
1	General Stability
16	Inhibitors
21	KM Value [mM]
3	Localization
8	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
41	Organism
7	Pathway
20	PDB ID
2	pH Optimum
1	pH Range
5	Protein Variants
4	Purification (Commentary)
4	Reaction
3	Reaction Type
33	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
46	Substrates and Products (Substrate)
5	Subunits
29	Synonyms
1	Systematic Name
18	Turnover Number [1/s]

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Application on EC 5.2.1.2 - maleylacetoacetate isomerase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

2 entries

additional information

Homo sapiens

-

knowledge of the GSTz1/MAAI haplotype can be used prospectively to identify individuals at potential risk of dichloroacetate’s adverse side effects from environmental or clinical exposure or who may exhibit aberrant amino acid metabolism in response to dietary protein

728222

medicine

Homo sapiens

O43708

cis and/or trans isomers of 2,4-dioxohept-2-enoic acid might be diagnostic for human deficiency of maleylacetoacetate isomerase

2468

medicine

Homo sapiens

O43708

dichloroacetate, a degradation product of chloral hydrate, is further metabolized by glutathione transferase zeta 1, and inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone. The amount of dichloroacetate produced from clinically relevant doses of chloral hydrate, although insufficient to alter dichloroacetate kinetics, is sufficient to inhibit MAAI and tyrosine catabolism

747644