5.2.1.2: maleylacetoacetate isomerase
This is an abbreviated version!
For detailed information about maleylacetoacetate isomerase, go to the full flat file.
Word Map on EC 5.2.1.2
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5.2.1.2
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dichloroacetate
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fumarylacetoacetate
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dca-induced
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succinylacetone
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chlorofluoroacetic
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homogentisate
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tyrosinemia
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medicine
- 5.2.1.2
- dichloroacetate
- fumarylacetoacetate
-
dca-induced
- succinylacetone
-
chlorofluoroacetic
- homogentisate
- tyrosinemia
- medicine
Reaction
Synonyms
AtGSTZ1, AtMAAI, glutathione S-transferase Zeta 1-1, glutathione S-transferase zeta-class 1, glutathione S-transferase zeta/maleylacetoacetate isomerase, glutathione transferase zeta, glutathione transferase zeta 1/maleylacetoacetate isomerase, Gstz1, GSTZ1-1, GSTz1/MAAI, GSTzeta/MAAI, Isomerase, maleylacetoacetate, MAAI, MAc-tI, maleylacetoacetate isomerase, Maleylacetoacetic isomerase, Maleylacetone cis-trans-isomerase, Maleylacetone isomerase, More
ECTree
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Engineering
Engineering on EC 5.2.1.2 - maleylacetoacetate isomerase
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C16A
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the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 2.1fold decreased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 1.6fold increased compared to wild-type enzyme
R175A
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the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 1.5fold decreased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 6.8fold decreased compared to wild-type enzyme
R175K
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the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 1.8fold increased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 1.3fold increased compared to wild-type enzyme
S14A
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mutant enzyme shows no activity with {(+/-)-2-bromo-3-(4-nitrophenyl)propionic acid} or 4-maleylacetoacetate
S15A
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the ratio of turnover number to KM-value for (+/-)-2-bromo-3-(4-nitrophenyl)propionic acid is 2.3fold decreased compared to the wild-type enzyme, the ratio of turnover number to KM-value for 4-maleylacetoacetate is 11.8fold decreased compared to wild-type enzyme