Disease on EC 5.2.1.2 - maleylacetoacetate isomerase
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Acidosis, Lactic
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
Acidosis, Lactic
Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
Acidosis, Lactic
Prenatal and postnatal expression of glutathione transferase ? 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Amyotrophic Lateral Sclerosis
Glutathione S-transferase Omega 2 DD genotype is associated with an increased risk of sporadic amyotrophic lateral sclerosis in Chinese men.
Breast Neoplasms
Investigation of glutathione S-transferase zeta and the development of sporadic breast cancer.
Breast Neoplasms
No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk.
Carcinogenesis
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Carcinoma, Hepatocellular
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Carcinoma, Hepatocellular
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Carcinoma, Hepatocellular
GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis.
Carcinoma, Hepatocellular
GSTZ1-1 downregulates Wnt/?-catenin signalling in hepatocellular carcinoma cells.
Hematologic Neoplasms
GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.
Liver Failure
Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase.
Lung Neoplasms
Pattern of antioxidant and DNA repair gene expression in normal airway epithelium associated with lung cancer diagnosis.
Macular Degeneration
Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1).
maleylacetoacetate isomerase deficiency
Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
maleylacetoacetate isomerase deficiency
Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.
maleylacetoacetate isomerase deficiency
Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic GSTs and NQO1.
maleylacetoacetate isomerase deficiency
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
maleylacetoacetate isomerase deficiency
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
maleylacetoacetate isomerase deficiency
Hypersuccinylacetonaemia and normal liver function in maleylacetoacetate isomerase deficiency.
maleylacetoacetate isomerase deficiency
Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer.
maleylacetoacetate isomerase deficiency
Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
maleylacetoacetate isomerase deficiency
Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta.
Multiple Myeloma
GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.
Neoplasms
Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate.
Neoplasms
GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway.
Neoplasms
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.
Neoplasms
GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Neoplasms
GSTZ1-1 downregulates Wnt/?-catenin signalling in hepatocellular carcinoma cells.
Neoplasms
p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.
Neoplasms
Prenatal and postnatal expression of glutathione transferase ? 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
Neuroblastoma
p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.
Ovarian Neoplasms
A panel of three oxidative stress-related genes predicts overall survival in ovarian cancer patients received platinum-based chemotherapy.
Pregnancy Complications
Effect modification of CPY2E1 and GSTZ1 genetic polymorphisms on associations between prenatal disinfection by-products exposure and birth outcomes.
Stomach Neoplasms
Glutathione S-transferase Z1 (GSTZ1) gene polymorphism in gastric cancer: a preliminary study in a Turkish population.
Tyrosinemias
Gene structure, chromosomal location, and expression pattern of maleylacetoacetate isomerase.
Urinary Bladder Neoplasms
A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire.
Urinary Bladder Neoplasms
Genotoxicity of disinfection byproducts and disinfected waters: A review of recent literature.
Urinary Bladder Neoplasms
Polymorphisms in GSTT1, GSTZ1, and CYP2E1, Disinfection Byproducts, and Risk of Bladder Cancer in Spain.
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