4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

This is an abbreviated version!
For detailed information about 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, go to the full flat file.

Reaction

Synonyms

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2-methylerythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase, cMEPP synthase, IspDF, IspE, IspF, MCS, MDS, ME-CPP synthase, MEC synthase, MECDP synthase, MECDP-synthase, MECP, MECPS, MECS, YGBB, YgbB protein

ECTree

     4 Lyases

         4.6 Phosphorus-oxygen lyases

             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

                4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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Results	in table
33706	AA Sequence
4	Application
1	CAS Registry Number
10	Cloned(Commentary)
12	Crystallization (Commentary)
7	Expression
4	General Information
78	IC50 Value
75	Inhibitors
4	KM Value [mM]
1	Localization
22	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
235	Organism
7	Pathway
217	PDB ID
2	pH Optimum
6	pI Value
2	Protein Variants
8	Purification (Commentary)
2	Reaction
2	Reaction Type
44	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
17	Subunits
54	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

14 entries

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

9 entries

4-diphosphocytidyl-2C-methyl-D-erythritol

2C-methyl-D-erythritol 3,4-cyclophosphate + CMP

Plasmodium falciparum

P62368

at low rate

655417

-

-

?

additional information

?

-

3 entries

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Arabidopsis thaliana

Q9CAK8

-

708124

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Brassica rapa

-

-

730270

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Escherichia coli

P62617

-

247122

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Escherichia coli

-

-

663548, 708124

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Escherichia coli

-

involved in mevalonate-independent biosynthesis of isoprenoids

656498

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Ginkgo biloba

Q1EDG4

-

666594

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Mycobacterium tuberculosis

-

-

714711

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Mycobacterium tuberculosis

P9WKG5

-

708124

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Mycobacterium tuberculosis H37Rv

-

-

714711

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Mycobacterium tuberculosis H37Rv

P9WKG5

-

708124

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Plasmodium falciparum

P62369

-

708124

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Plasmodium falciparum NF54

P62369

-

708124

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Rauvolfia verticillata

-

-

730628

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Stevia rebaudiana

Q0Q5B3

-

730357

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Cephalotaxus harringtonia

-

-

694098

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Escherichia coli

P62617

-

247122, 656112, 657177

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Escherichia coli

-

-

657177

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Hevea brasiliensis

A9ZN12

-

691382

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Mycobacterium tuberculosis

-

-

695176

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Mycobacterium tuberculosis Rv3582c

-

-

695176

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Plasmodium falciparum

P62368

-

655417

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Plasmodium falciparum

P62368

at low rate

655417

-

-

?

2-phospho-4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol

2C-methyl-D-erythritol-2,4-cyclodiphosphate + CMP

Plasmodium falciparum

P62368

nonmevalonate pathway of isoprenoid biosynthesis

655417

-

-

?

additional information

?

-

Agrobacterium tumefaciens

-

bifunctional 4-diphosphocytidyl-2C-methyl-D-erythritol synthase/2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase enzyme associates in solution with 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, i.e. ispE protein. No evidence for substrate channeling during the three enzyme’s subsequent catalytic reactions

672138

-

-

?

additional information

?

-

Escherichia coli

-

depletion of MEC synthase has an early and significant impact on cell wall biosynthesis and leads ultimately to cell death

655848

-

-

?

additional information

?

-

Taxus x media

D3G6G3

active site including CDP-binding sites (Asp140Gly142 and Leu184Leu189Ser190Lys216Thr217Glu219). Owns a 60 amino-acid plastidial transit peptide at its N-terminus

709487

-

-

?