4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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For detailed information about 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, go to the full flat file.

Reaction

Synonyms

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2-methylerythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase, cMEPP synthase, IspDF, IspE, IspF, MCS, MDS, ME-CPP synthase, MEC synthase, MECDP synthase, MECDP-synthase, MECP, MECPS, MECS, YGBB, YgbB protein

ECTree

     4 Lyases

         4.6 Phosphorus-oxygen lyases

             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)

                4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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Results	in table
33706	AA Sequence
4	Application
1	CAS Registry Number
10	Cloned(Commentary)
12	Crystallization (Commentary)
7	Expression
4	General Information
78	IC50 Value
75	Inhibitors
4	KM Value [mM]
1	Localization
22	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
235	Organism
7	Pathway
217	PDB ID
2	pH Optimum
6	pI Value
2	Protein Variants
8	Purification (Commentary)
2	Reaction
2	Reaction Type
44	Reference
18	Source Tissue
1	Specific Activity [micromol/min/mg]
29	Substrates and Products (Substrate)
17	Subunits
54	Synonyms
1	Systematic Name
3	Turnover Number [1/s]

Engineering

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Engineering on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Arg142Met, Glu144Leu

Escherichia coli

-

dual mutation with little influence on both the overall structure and the detail in the active site

663548

additional information

Arabidopsis thaliana

-

Arabidopsis enzyme null mutants are albino lethal. Chloroplasts of mutants are filled with vesicles instead of thylakoids. Expression of enzyme in Escherichia coli can rescue the lethal phenotype of an Escherichia coli ispF mutant

682464