4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

This is an abbreviated version!
For detailed information about 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, go to the full flat file.

Word Map on EC 4.6.1.12

Reaction

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
=
2-C-methyl-D-erythritol 2,4-cyclodiphosphate
+
CMP

Synonyms

MECDP-synthase, MECPS, MCS, YgbB protein, MECDP synthase, IspDF, IspE, MEC synthase, 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase, MECS, MECP, cMEPP synthase, IspF, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, YGBB, 2-methylerythritol 2,4-cyclodiphosphate synthase, 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, ME-CPP synthase, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, MDS, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase

ECTree

     4 Lyases
         4.6 Phosphorus-oxygen lyases
             4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
                4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Expression

Expression on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
abscisic acid does not modulate enzyme expression
at 4°C, the enzyme expression is down-regulated at 0.05-0.1 mM indole 3-acetic acid. Methyl jasmonate and kinetin down-regulate the expression at 2 h and onwards
enzyme expression in seedlings treated with abscisic acid, H2O2 and drought is higher than in control seedlings
-
enzyme expression is higher in response to light as compared to plants kept under dark.The enzyme also exhibits a gradual up-regulation up to 6 h in response to gibberellic acid treatment
enzyme expression is up-regulated by exogenous elicitors including 0.1 mM methyl jasmonate, acetyl salicylic acid, absisic acid, and UV light
-
expression of genes encoding 1-deoxy-D-xylulose 5-phosphate synthase (DXS), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) and 2-C-methyl-D-erytrithol 2,4-cyclodiphosphate synthase (MDS) is upregulated in plants inoculated with arbuscular mycorrhizal fungi. Presence of Zn and Mn is required from the expresssion of MDS, their enhanced uptake in inoculated plants could be responsible for the increased transcription of MDS.
-
higher expression levels in tender barks and leaves than that in roots and stems