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Information on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

for references in articles please use BRENDA:EC4.6.1.12
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IUBMB Comments
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
mecs, mecps, ispdf, 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase, 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase, ygbb protein, mec synthase, 2-methylerythritol 2,4-cyclodiphosphate synthase, mecdp synthase, 2-c-methyl-d-erythritol-2,4-cyclodiphosphate synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP
show the reaction diagram
; The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis
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