4.4.1.11: methionine gamma-lyase

This is an abbreviated version!
For detailed information about methionine gamma-lyase, go to the full flat file.

Reaction

Synonyms

CalE6, EhMGL1, EhMGL2, fer1MgL2, Fn1419, L-methionase, L-methioninase, L-methionine gamma-lyase, L-methionine gamma-lyase 1, L-methionine-alpha-deamino-gamma-mercaptomethane lyase, L-methionine-alpha-deamino-gamma-mercaptomethane-lyase, L-methionine-gamma-lyase, lyase, methionine, MdeA, MegL, METase, methioninase, methionine alpha,gamma-lyase, methionine dethiomethylase, methionine gamma-lyase, methionine lyase, methionine-gamma-lyase, MGL, MGL1, MGL2, rMETase, sav7062, TvMGL1, TvMGL2, YtjE

ECTree

     4 Lyases

         4.4 Carbon-sulfur lyases

             4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

                4.4.1.11 methionine gamma-lyase

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Results	in table
1	Activating Compound
6836	AA Sequence
53	Application
1	CAS Registry Number
45	Cloned(Commentary)
85	Cofactor
44	Crystallization (Commentary)
1089	Disease/ Diagnostics
7	Expression
17	General Information
7	General Stability
6	IC50 Value
133	Inhibitors
79	kcat/KM [mM/s]
7	Ki Value [mM]
221	KM Value [mM]
18	Localization
18	Metals/Ions
71	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
196	Organism
2	Oxidation Stability
8	Pathway
141	PDB ID
26	pH Optimum
7	pH Range
18	pH Stability
4	pI Value
1	Posttranslational Modification
73	Protein Variants
72	Purification (Commentary)
8	Reaction
3	Reaction Type
166	Reference
11	Source Tissue
93	Specific Activity [micromol/min/mg]
6	Storage Stability
318	Substrates and Products (Substrate)
49	Subunits
159	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
159	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.4.1.11 - methionine gamma-lyase

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SYSTEMATIC NAME

IUBMB Comments

L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)

A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme is involved in L-methionine catabolism.