Disease on EC 4.4.1.11 - methionine gamma-lyase
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Adrenocortical Carcinoma
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Amebiasis
Crystallization and preliminary X-ray analysis of L-methionine gamma-lyase 1 from Entamoeba histolytica.
Anaphylaxis
PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates.
Anaphylaxis
Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.
Arthritis
Anti-inflammatory activity of myricetin-3-O-beta-D-glucuronide and related compounds.
Arthritis
Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats.
Ataxia
Astroglial monoacylglycerol lipase controls mutant huntingtin-induced damage of striatal neurons.
Atherosclerosis
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
Atherosclerosis
Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.
Autoimmune Diseases
Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.
Brain Diseases
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats.
Breast Neoplasms
A Nature-Inspired Metal-Organic Framework Discriminator for Differential Diagnosis of Cancer Cell Subtypes.
Breast Neoplasms
Influence of L-methioninase targeted to the urokinase receptor on the proliferation and motility of lung and prostate cancer cells.
Breast Neoplasms
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.
Breast Neoplasms
Magnolin Inhibits Proliferation and Invasion of Breast Cancer MDA-MB-231 Cells by Targeting the ERK1/2 Signaling Pathway.
Breast Neoplasms
Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons.
Breast Neoplasms
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Breast Neoplasms
Purification, characterization and anticancer evaluation of l-methioninase from Trichoderma harzianum.
Breast Neoplasms
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Breast Neoplasms
Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients.
Breast Neoplasms
Targeting a methioninase-containing fusion protein to breast cancer urokinase receptors inhibits growth and migration.
Breast Neoplasms
Targeting of a novel fusion protein containing methioninase to the urokinase receptor to inhibit breast cancer cell migration and proliferation.
Carcinogenesis
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms.
Carcinogenesis
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Carcinogenesis
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase.
Carcinogenesis
Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma.
Carcinoma
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Carcinoma
Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages.
Carcinoma
Evaluation of METase-pemetrexed-loaded PEG-PLGA nanoparticles modified with anti-CD133-scFV for treatment of gastric carcinoma.
Carcinoma
Evaluation of rMETase-Loaded Stealth PLGA/Liposomes Modified with Anti-CAGE scFV for Treatment of Gastric Carcinoma.
Carcinoma
Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model.
Carcinoma
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.
Carcinoma
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Carcinoma
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase.
Carcinoma
Oral recombinant methioninase combined with paclitaxel arrests recalcitrant ovarian clear cell carcinoma growth in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Carcinoma
Stealth cationic liposomes modified with anti-CAGE single-chain fragment variable deliver recombinant methioninase for gastric carcinoma therapy.
Carcinoma
The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.
Carcinoma, Adenosquamous
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Carcinoma, Hepatocellular
Purification, characterization and anticancer evaluation of l-methioninase from Trichoderma harzianum.
Carcinoma, Hepatocellular
The cyanobacterial oligopeptides microginins induce DNA damage in the human hepatocellular carcinoma (HepG2) cell line.
Carcinoma, Lewis Lung
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Carcinoma, Non-Small-Cell Lung
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Carcinoma, Squamous Cell
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Cholangitis, Sclerosing
Monoacylglycerol lipase inhibition protects from liver injury in mouse models of sclerosing cholangitis.
Cholesteatoma
Expression of C-type lectin receptor mRNA in chronic otitis media with cholesteatoma.
Colitis, Ulcerative
Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis.
Colitis, Ulcerative
Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis.
Colonic Neoplasms
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Colonic Neoplasms
Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.
Colonic Neoplasms
Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.
Colonic Neoplasms
Endosomal escape by photo-activated fusion of liposomes containing a malachite green derivative: a novel class of photoresponsive liposomes for drug delivery vehicles.
Colonic Neoplasms
Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells.
Colonic Neoplasms
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.
Colonic Neoplasms
Oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil regressed a colon cancer growing on the peritoneal surface in a patient-derived orthotopic xenograft mouse model.
Colonic Neoplasms
Recombinant Engineering of L-Methioninase Using Two Different Promoter and Expression Systems and in vitro Analysis of Its Anticancer Efficacy on Different Human Cancer Cell Lines.
Colorectal Neoplasms
Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines.
Colorectal Neoplasms
N-Glycoproteins Have a Major Role in MGL Binding to Colorectal Cancer Cell Lines: Associations with Overall Proteome Diversity.
Colorectal Neoplasms
Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3.
Colorectal Neoplasms
Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer.
Colorectal Neoplasms
The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.
Communicable Diseases
Methionine gamma-lyase: The unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers.
Cysts
[Evaluation of Giardia lamblia detection method in stool specimens fixed with SAF solution]
Diabetes Mellitus, Type 2
Inhibition of monoglyceride lipase by proton pump inhibitors: investigation using docking and in vitro experiments.
Diabetic Retinopathy
Correlation of the retinopathy degree with the change of ocular surface and corneal nerve in patients with type 2 diabetes mellitus.
Dry Eye Syndromes
The influence of meibomian gland loss on ocular surface clinical parameters.
Dyslipidemias
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
Encephalomyelitis
Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation.
Encephalomyelitis, Autoimmune, Experimental
Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation.
Fibrosarcoma
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Glaucoma
Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment.
Glioblastoma
Computational elucidation of phylogenetic, functional and structural features of Methioninase from Pseudomonas, Escherichia, Clostridium and Citrobacter strains.
Glomerulonephritis, Membranoproliferative
Discriminant analysis in renal histological diagnosis of primary glomerular diseases.
Graft vs Host Disease
Effects of magnesium isoglycyrrhizinate on AST, ALT, and serum levels of Th1 cytokines in patients with allo-HSCT.
Graft vs Host Disease
Longitudinal Analysis of Infrared Meibography in Patients Undergoing Hematopoietic Stem Cell Transplantation.
Heart Diseases
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Hepatitis
Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4(+)CD25(-)CD69(+) subset proliferation.
Hepatitis, Autoimmune
Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition of CD4(+)CD25(-)CD69(+) subset proliferation.
Hyperalgesia
Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine?
Hyperglycemia
The impact of glycemic variability on length of stay and mortality in diabetic patients admitted with community-acquired pneumonia or chronic obstructive pulmonary disease.
Hypersensitivity
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.
Hypersensitivity
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.
Hypoglycemia
Effect of glycemic gap upon mortality in critically ill patients with diabetes.
Hypoglycemia
The impact of glycemic variability on length of stay and mortality in diabetic patients admitted with community-acquired pneumonia or chronic obstructive pulmonary disease.
Infections
Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry.
Infections
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Infections
The C-type lectin receptor MGL senses N-acetylgalactosamine on the unique Staphylococcus aureus ST395 wall teichoic acid.
Influenza, Human
Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry.
Insulin Resistance
Flavonoids Fraction of Mespilus Germanica Alleviates Insulin Resistance in Metabolic Syndrome Model of Ovariectomized Rats via Reduction in Tumor Necrosis Factor-?.
Kidney Neoplasms
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Kidney Neoplasms
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Kidney Neoplasms
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Leukemia, T-Cell
Glycoproteomic analysis of MGL binding proteins on acute T cell leukemia cells.
Liposarcoma
Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma.
Liposarcoma
Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma.
Liver Diseases
Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
Liver Diseases
Monoacylglycerol lipase reprograms lipid precursors signaling in liver disease.
Liver Diseases
Oral Recombinant Methioninase Prevents Nonalcoholic Fatty Liver Disease in Mice on a High Fat Diet.
Lung Neoplasms
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Lung Neoplasms
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).
Lung Neoplasms
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
Lung Neoplasms
Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts.
Lung Neoplasms
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase.
Lung Neoplasms
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Lung Neoplasms
Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.
Lung Neoplasms
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Lung Neoplasms
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Lung Neoplasms
Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model.
Lymphatic Metastasis
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Lymphoma
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Lymphoma
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Lymphoma, B-Cell
Magnolin Inhibits Proliferation and Invasion of Breast Cancer MDA-MB-231 Cells by Targeting the ERK1/2 Signaling Pathway.
Medulloblastoma
Computational elucidation of phylogenetic, functional and structural features of Methioninase from Pseudomonas, Escherichia, Clostridium and Citrobacter strains.
Meibomian Gland Dysfunction
Age differences in ocular demodicosis: Demodex profiles and clinical manifestations.
Melanoma
Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro.
Melanoma
Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma.
Melanoma
Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
Melanoma
High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.
Melanoma
Long exposure of non-cytotoxic concentrations of methylselenol suppresses the invasive potential of B16F10 melanoma.
Melanoma
Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells.
Melanoma
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Melanoma
Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
Melanoma
Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.
Melanoma
Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.
methionine gamma-lyase deficiency
Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
methionine gamma-lyase deficiency
Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic ?-opioid receptor sensitivity.
Multiple Myeloma
A quantitative method for the characterization of lytic metastases of the bone from radiographic images.
Multiple Sclerosis
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain.
Neoplasm Metastasis
A quantitative method for the characterization of lytic metastases of the bone from radiographic images.
Neoplasm Metastasis
Adjuvant Oral Recombinant Methioninase Inhibits Lung Metastasis in a Surgical Breast-Cancer Orthotopic Syngeneic Model.
Neoplasm Metastasis
Efficacy of Oral Recombinant Methioninase and Eribulin on a PDOX Model of Triple-negative Breast Cancer (TNBC) Liver Metastasis.
Neoplasm Metastasis
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Neoplasm Metastasis
Oral Recombinant Methioninase Overcomes Colorectal-cancer Liver Metastasis Resistance to the Combination of 5-Fluorouracil and Oxaliplatinum in a Patient-derived Orthotopic Xenograft Mouse Model.
Neoplasm Metastasis
Oral Recombinant Methioninase Sensitizes a Bladder Cancer Orthotopic Xenograft Mouse Model to Low-dose Cisplatinum and Prevents Metastasis.
Neoplasm Metastasis
Response of Triple-negative Breast Cancer Liver Metastasis to Oral Recombinant Methioninase in a Patient-derived Orthotopic Xenograft (PDOX) Model.
Neoplasm Metastasis
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chemotherapy moves toward the clinic.
Neoplasms
A Nature-Inspired Metal-Organic Framework Discriminator for Differential Diagnosis of Cancer Cell Subtypes.
Neoplasms
A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension.
Neoplasms
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase.
Neoplasms
Broad selective efficacy of recombinant methioninase and polyethylene glycol-modified recombinant methioninase on cancer cells In Vitro.
Neoplasms
Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells.
Neoplasms
Characterization of Macrophage Galactose-type Lectin (MGL) ligands in colorectal cancer cell lines.
Neoplasms
Chronic Treatment of an Advanced Prostate-cancer Patient With Oral Methioninase Resulted in Long-term Stabilization of Rapidly Rising PSA Levels.
Neoplasms
Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate.
Neoplasms
Clonostachys rosea demethiolase STR3 controls the conversion of methionine into methanethiol.
Neoplasms
Combination therapy of tumor-targeting Salmonella typhimurium A1-R and oral recombinant methioninase regresses a BRAF-V600E-negative melanoma.
Neoplasms
Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.
Neoplasms
Computational elucidation of phylogenetic, functional and structural features of Methioninase from Pseudomonas, Escherichia, Clostridium and Citrobacter strains.
Neoplasms
Conjugates of methionine ?-lyase with polysialic acid: Two approaches to antitumor therapy.
Neoplasms
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Neoplasms
Crystallization and preliminary crystallographic characterization of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane lyase (methioninase).
Neoplasms
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).
Neoplasms
Docking based virtual screening and molecular dynamics study to identify potential monoacylglycerol lipase inhibitors.
Neoplasms
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms.
Neoplasms
Effect of the methanolic extract of Glinus lotoides on Dalton's ascitic lymphoma.
Neoplasms
Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase.
Neoplasms
Effects in Cancer Cells of the Recombinant l-Methionine Gamma-Lyase from Brevibacterium aurantiacum. Encapsulation in Human Erythrocytes for Sustained l-Methionine Elimination.
Neoplasms
Efficacy of oral recombinant methioninase combined with oxaliplatinum and 5-fluorouracil on primary colon cancer in a patient-derived orthotopic xenograft mouse model.
Neoplasms
Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review.
Neoplasms
Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.
Neoplasms
Enzyme prodrug therapy designed to target L-methioninase to the tumor vasculature.
Neoplasms
Evaluation of rMETase-Loaded Stealth PLGA/Liposomes Modified with Anti-CAGE scFV for Treatment of Gastric Carcinoma.
Neoplasms
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.
Neoplasms
Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase.
Neoplasms
Gene cloning, characterization, and cytotoxic activity of methionine ?-lyase from Clostridium novyi.
Neoplasms
High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.
Neoplasms
Histone methylation status of H3K4me3 and H3K9me3 under methionine restriction is unstable in methionine-addicted cancer cells, but stable in normal cells.
Neoplasms
Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells.
Neoplasms
In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.
Neoplasms
Influence of L-methioninase targeted to the urokinase receptor on the proliferation and motility of lung and prostate cancer cells.
Neoplasms
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Neoplasms
Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model.
Neoplasms
Interactions between the breast cancer-associated MUC1 mucins and C-type lectin characterized by optical tweezers.
Neoplasms
Investigating Patterns of Immune Interaction in Ovarian Cancer: Probing the O-glycoproteome by the Macrophage Galactose-Like C-type Lectin (MGL).
Neoplasms
Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase.
Neoplasms
Metabolic targeting with recombinant methioninase combined with palbociclib regresses a doxorubicin-resistant dedifferentiated liposarcoma.
Neoplasms
METase promotes cell autophagy via promoting SNHG5 and suppressing miR-20a in gastric cancer.
Neoplasms
Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate.
Neoplasms
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Neoplasms
Methioninase gene therapy with selenomethionine induces apoptosis in bcl-2-overproducing lung cancer cells.
Neoplasms
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Neoplasms
Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.
Neoplasms
Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts.
Neoplasms
Methionine Gamma Lyase from Clostridium sporogenes Increases the Anticancer Efficacy of Doxorubicin on A549 Cancer Cells In Vitro and Human Cancer Xenografts.
Neoplasms
Methionine gamma-lyase: The unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers.
Neoplasms
Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
Neoplasms
Methionine starvation modulates the efficacy of cisplatin on human breast cancer in nude mice.
Neoplasms
Methionine tumor starvation by erythrocyte-encapsulated methionine gamma-lyase activity controlled with per os vitamin B6.
Neoplasms
Methods to Study the Role of Methionine-Restricted Diet and Methioninase in Cancer Growth Control.
Neoplasms
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.
Neoplasms
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Neoplasms
Microbial L-methioninase: production, molecular characterization, and therapeutic applications.
Neoplasms
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Neoplasms
Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma.
Neoplasms
Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein.
Neoplasms
N-Glycosylation of mollusk hemocyanins contributes to their structural stability and immunomodulatory properties in mammals.
Neoplasms
Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient.
Neoplasms
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Neoplasms
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
Neoplasms
Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
Neoplasms
Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates.
Neoplasms
Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine.
Neoplasms
Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer.
Neoplasms
Preparation of Internalizing RGD-Modified Recombinant Methioninase Exosome Active Targeting Vector and Antitumor Effect Evaluation.
Neoplasms
Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation.
Neoplasms
Purification, characterization and anticancer evaluation of l-methioninase from Trichoderma harzianum.
Neoplasms
Purification, Characterization of L-Methioninase from Candida tropicalis, and Its Application as an Anticancer.
Neoplasms
Recombinant Engineering of L-Methioninase Using Two Different Promoter and Expression Systems and in vitro Analysis of Its Anticancer Efficacy on Different Human Cancer Cell Lines.
Neoplasms
Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models.
Neoplasms
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
Neoplasms
Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma.
Neoplasms
Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Neoplasms
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
Neoplasms
Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.
Neoplasms
Safety and Toxicity of Recombinant Methioninase and Polyethylene Glycol (PEG) Recombinant Methioninase in Primates.
Neoplasms
Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.
Neoplasms
Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients.
Neoplasms
Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model.
Neoplasms
Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase.
Neoplasms
Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
Neoplasms
Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.
Neoplasms
Targeting of a novel fusion protein containing methioninase to the urokinase receptor to inhibit breast cancer cell migration and proliferation.
Neoplasms
The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL.
Neoplasms
The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma.
Neoplasms
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.
Neoplasms
The Plasticity of Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin.
Neoplasms
The preparation of endotoxin-free L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Pseudomonas putida.
Neoplasms
The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes.
Neoplasms
Treatment of cancer cells with methioninase produces DNA hypomethylation and increases DNA synthesis.
Neoplasms
Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.
Neoplasms
Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction.
Neoplasms
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chemotherapy moves toward the clinic.
Neuralgia
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment.
Neuralgia
Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol.
Neuralgia
Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.
Neuroblastoma
Computational elucidation of phylogenetic, functional and structural features of Methioninase from Pseudomonas, Escherichia, Clostridium and Citrobacter strains.
Neuroblastoma
Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs.
Neurodegenerative Diseases
Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism.
Neurodegenerative Diseases
Refined homology model of monoacylglycerol lipase: toward a selective inhibitor.
Neuroinflammatory Diseases
ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase.
Neuroinflammatory Diseases
Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation.
Neuroinflammatory Diseases
Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling.
Non-alcoholic Fatty Liver Disease
Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
Non-alcoholic Fatty Liver Disease
Oral Recombinant Methioninase Prevents Nonalcoholic Fatty Liver Disease in Mice on a High Fat Diet.
Non-alcoholic Fatty Liver Disease
Prevention of free fatty acid-induced hepatic lipotoxicity in HepG2 cells by magnesium isoglycyrrhizinate in vitro.
Obesity
Erratum: Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.
Obesity
Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity.
Obesity
Investigations of the human endocannabinoid system in two subcutaneous adipose tissue depots in lean subjects and in obese subjects before and after weight loss.
Obesity
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Osteosarcoma
Effective Metabolic Targeting of Human Osteosarcoma Cells In Vitro and in Orthotopic Nude-mouse Models with Recombinant Methioninase.
Osteosarcoma
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
Osteosarcoma
Oral-recombinant Methioninase Converts an Osteosarcoma from Docetaxel-resistant to -Sensitive in a Clinically-relevant Patient-derived Orthotopic-xenograft (PDOX) Mouse Model.
Osteosarcoma
The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model.
Osteosarcoma
Tumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: Decoy, trap and kill chemotherapy moves toward the clinic.
Ovarian Neoplasms
Investigating Patterns of Immune Interaction in Ovarian Cancer: Probing the O-glycoproteome by the Macrophage Galactose-Like C-type Lectin (MGL).
Ovarian Neoplasms
Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.
Ovarian Neoplasms
Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient.
Ovarian Neoplasms
Recombinant Engineering of L-Methioninase Using Two Different Promoter and Expression Systems and in vitro Analysis of Its Anticancer Efficacy on Different Human Cancer Cell Lines.
Pancreatic Neoplasms
Oral recombinant methioninase (o-rMETase) is superior to injectable rMETase and overcomes acquired gemcitabine resistance in pancreatic cancer.
Pancreatic Neoplasms
Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model.
Pancreatic Neoplasms
Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.
Pancreatic Neoplasms
Triple-Methyl Blockade With Recombinant Methioninase, Cycloleucine, and Azacitidine Arrests a Pancreatic Cancer Patient-Derived Orthotopic Xenograft Model.
Papilloma
Initiating activity of eight pyrolysates of carbohydrates in a two-stage mouse skin tumorigenesis model.
Parkinson Disease
Methioninase: a therapeutic for diseases related to altered methionine metabolism and transmethylation: cancer, heart disease, obesity, aging, and Parkinson's disease.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Effect of nutritional and enzymatic methionine deprivation upon human normal and malignant cells in tissue culture.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Tumor therapy by deprivation of L-methionine: rationale and results.
Prostatic Neoplasms
Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells.
Prostatic Neoplasms
Broad selective efficacy of rMETase and PEG-rMETase on cancer cells in vitro.
Prostatic Neoplasms
Chronic Treatment of an Advanced Prostate-cancer Patient With Oral Methioninase Resulted in Long-term Stabilization of Rapidly Rising PSA Levels.
Prostatic Neoplasms
Induction of caspase-mediated apoptosis and cell-cycle G1 arrest by selenium metabolite methylselenol.
Prostatic Neoplasms
Influence of L-methioninase targeted to the urokinase receptor on the proliferation and motility of lung and prostate cancer cells.
Prostatic Neoplasms
Oral dosing of Recombinant Methioninase Is Associated With a 70% Drop in PSA in a Patient With Bone-metastatic Prostate Cancer and 50% Reduction in Circulating Methionine in a High-stage Ovarian Cancer Patient.
Prostatic Neoplasms
Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase.
Proteinuria
An unusual manifestation in a patient with adult-onset Still's disease: Minimal glomerular lesion.
Retinoblastoma
Activity of Se-allylselenocysteine in the presence of methionine gamma-lyase on cell growth, DNA integrity, apoptosis, and cell-cycle regulatory molecules.
Retinoblastoma
Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms.
Sarcoma
Combination of oral recombinant methioninase and decitabine arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma patient-derived orthotopic xenograft mouse model.
Sarcoma
Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.
Sarcoma
Oral Recombinant Methioninase, Combined With Oral Caffeine and Injected Cisplatinum, Overcome Cisplatinum-Resistance and Regresses Patient-derived Orthotopic Xenograft Model of Osteosarcoma.
Sarcoma
Recombinant Methioninase Combined With Tumor-targeting Salmonella typhimurium A1-R Induced Regression in a PDOX Mouse Model of Doxorubicin-resistant Dedifferentiated Liposarcoma.
Sarcoma
Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
Sarcoma, Ewing
Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.
Sarcoma, Ewing
High Efficacy of Recombinant Methioninase on Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer.
Sarcoma, Ewing
Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Sarcoma, Synovial
Oral Recombinant Methioninase Combined with Caffeine and Doxorubicin Induced Regression of a Doxorubicin-resistant Synovial Sarcoma in a PDOX Mouse Model.
Sarcoma, Synovial
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.
Seizures
Audiogenic seizure sensitivity in mouse lines genetically selected for high versus low blood magnesium levels.
Sepsis
Hyperglycemia and glycemic variability are associated with the severity of sepsis in nondiabetic subjects.
Starvation
Computational elucidation of phylogenetic, functional and structural features of Methioninase from Pseudomonas, Escherichia, Clostridium and Citrobacter strains.
Starvation
Intestinal monoacylglycerol metabolism: developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase.
Starvation
Methionine tumor starvation by erythrocyte-encapsulated methionine gamma-lyase activity controlled with per os vitamin B6.
Stomach Neoplasms
A novel design of HA-coated nanoparticles co-encapsulating plasmid METase and 5-Fu shows enhanced application in targeting gastric cancer stem cells.
Stomach Neoplasms
Difficulty in distinguishing malignant gastric lymphoma from advanced gastric cancer: Focusing on endoscopic findings of the Borrmann type.
Stomach Neoplasms
Evaluation of rMETase-Loaded Stealth PLGA/Liposomes Modified with Anti-CAGE scFV for Treatment of Gastric Carcinoma.
Stomach Neoplasms
Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells.
Stomach Neoplasms
METase promotes cell autophagy via promoting SNHG5 and suppressing miR-20a in gastric cancer.
Stomach Neoplasms
METase/lncRNA HULC/FoxM1 reduced cisplatin resistance in gastric cancer by suppressing autophagy.
Stomach Neoplasms
Stealth cationic liposomes modified with anti-CAGE single-chain fragment variable deliver recombinant methioninase for gastric carcinoma therapy.
Stomach Neoplasms
The mechanism study of lentiviral vector carrying methioninase enhances the sensitivity of drug-resistant gastric cancer cells to Cisplatin.
Stomach Neoplasms
Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.
Stomach Neoplasms
[Recombinant methioninase regulates PI3K/Akt/Glut-1 pathway and inhibits aerobic glycolysis to promote apoptosis of gastric cancer cells].
Stomach Ulcer
Effect of pyridoxine and magnesium on stress-induced gastric ulcers in mice selected for low or high blood magnesium levels.
Triple Negative Breast Neoplasms
Efficacy of Oral Recombinant Methioninase and Eribulin on a PDOX Model of Triple-negative Breast Cancer (TNBC) Liver Metastasis.
Triple Negative Breast Neoplasms
Oral Methioninase Inhibits Recurrence in a PDOX Mouse Model of Aggressive Triple-negative Breast Cancer.
Triple Negative Breast Neoplasms
Response of Triple-negative Breast Cancer Liver Metastasis to Oral Recombinant Methioninase in a Patient-derived Orthotopic Xenograft (PDOX) Model.
Tuberculosis
Complement activation by mycoloyl glycolipids from Mycobacterium tuberculosis and Rhodococcus ruber.
Tuberculosis
Novel Role for Macrophage Galactose-Type Lectin-1 to Regulate Innate Immunity against Mycobacterium tuberculosis.
Tuberculosis
[Culture of mycobacterium tuberculosis of gastric juice collected through different ways in diagnosis of pulmonary tuberculosis in children]
Urinary Bladder Neoplasms
Oral Recombinant Methioninase Sensitizes a Bladder Cancer Orthotopic Xenograft Mouse Model to Low-dose Cisplatinum and Prevents Metastasis.
Uterine Cervical Neoplasms
MGL Ligand Expression Is Correlated to Lower Survival and Distant Metastasis in Cervical Squamous Cell and Adenosquamous Carcinoma.
Virus Diseases
Macrophage receptors for influenza A virus: role of the macrophage galactose-type lectin and mannose receptor in viral entry.
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