4.4.1.11: methionine gamma-lyase

This is an abbreviated version!
For detailed information about methionine gamma-lyase, go to the full flat file.

Word Map on EC 4.4.1.11

4.4.1.11

lipase

monoacylglycerol

endocannabinoids

cannabinoids

lectin

putida

c-type

2-arachidonoylglycerol

pyridoxal

medicine

monoglyceride

orthotopic

galactose-type

galnac

selenomethionine

anandamide

freundii

2-arachidonoyl

citrobacter

alpha-ketobutyrate

methylselenol

meibomian

methionine-dependent

mercaptan

beta-lyase

5'-phosphate-dependent

dc-sign

s-substituted

synthesis

nutrition

environmental protection

analysis

drug development

Reaction

Synonyms

CalE6, EhMGL1, EhMGL2, fer1MgL2, Fn1419, L-methionase, L-methioninase, L-methionine gamma-lyase, L-methionine gamma-lyase 1, L-methionine-alpha-deamino-gamma-mercaptomethane lyase, L-methionine-alpha-deamino-gamma-mercaptomethane-lyase, L-methionine-gamma-lyase, lyase, methionine, MdeA, MegL, METase, methioninase, methionine alpha,gamma-lyase, methionine dethiomethylase, methionine gamma-lyase, methionine lyase, methionine-gamma-lyase, MGL, MGL1, MGL2, rMETase, sav7062, TvMGL1, TvMGL2, YtjE

ECTree

4 Lyases

4.4 Carbon-sulfur lyases

4.4.1 Carbon-sulfur lyases (only sub-subclass identified to date)

4.4.1.11 methionine gamma-lyase

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Results	in table
1	Activating Compound
6836	AA Sequence
53	Application
1	CAS Registry Number
45	Cloned(Commentary)
85	Cofactor
44	Crystallization (Commentary)
1089	Disease/ Diagnostics
7	Expression
17	General Information
7	General Stability
6	IC50 Value
133	Inhibitors
79	kcat/KM [mM/s]
7	Ki Value [mM]
221	KM Value [mM]
18	Localization
18	Metals/Ions
71	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
196	Organism
2	Oxidation Stability
8	Pathway
141	PDB ID
26	pH Optimum
7	pH Range
18	pH Stability
4	pI Value
1	Posttranslational Modification
73	Protein Variants
72	Purification (Commentary)
8	Reaction
3	Reaction Type
166	Reference
11	Source Tissue
93	Specific Activity [micromol/min/mg]
6	Storage Stability
318	Substrates and Products (Substrate)
49	Subunits
159	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
159	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 4.4.1.11 - methionine gamma-lyase

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Pseudomonas putida

several days without loss of activity

34519

4 entries

Aeromonas sp.

18% loss of activity, 5 min

34521

Pseudomonas putida

P13254

purified mutant D241R, loss of 70% activity

purified wild-type enzyme and mutants, inactivation of all besides mutants D241E, and K240N, retaining 20% and K240M retaining 10% activity, respectively

729426