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4.2.1.46: dTDP-glucose 4,6-dehydratase

This is an abbreviated version!
For detailed information about dTDP-glucose 4,6-dehydratase, go to the full flat file.

Word Map on EC 4.2.1.46

Reaction

dTDP-alpha-D-glucose
=
dTDP-4-dehydro-6-deoxy-alpha-D-glucose
+
H2O

Synonyms

DesIV, dTDP-D-glucose 4,6-dehydratase, dTDP-D-glucose oxidoreductase, dTDP-glucose-4,6-dehydratase, dTGD, RmbB, rml-2, RmlB, TDP-D-glucose 4,6-dehydratase, TDP-glucose oxidoreductase, TDPDH, Thymidine diphosphate D-glucose oxidoreductase, thymidine diphosphate-glucose 4,6-dehydratase, Thymidine diphospho-D-glucose 4,6-dehydratase, Thymidine diphosphoglucose oxidoreductase, UDP-D-glucose 4,6-dehydratase, Ugd

ECTree

     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.46 dTDP-glucose 4,6-dehydratase

Specific Activity

Specific Activity on EC 4.2.1.46 - dTDP-glucose 4,6-dehydratase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.04
-
dTDPglucose
0.2
-
dTDPglucose
0.31
-
dTDPglucose
0.4
-
dTDPglucose
1.5
-
dTDP-3-azido-3-deoxyglucose
12.3
-
dTDPglucose
2
-
dTDPglucose
2.2
-
dTDP-3-deoxyglucose
4.2
-
dTDPglucose
4.3
-
dTDPglucose
additional information
involved in initial steps of biosynthesis of the S-layer glycan component dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose (Quip3NAc), chromosomal organization shown, gene homologues in Gram-negative as well as in antibiotic-producing Gram-positive bacteria, also key enzyme in the biosynthetic pathway of dTDP-beta-L-rhamnose, biosynthesis pathway may also be valid for LPS (lipopolysaccharide) O-antigen structures and antibiotic precursors